CD32

Fc fragment of IgG, low affinity IIa, receptor (CD32)
Identifiers
Symbol FCGR2A
Alt. symbols FCG2, FCGR2A1, FCGR2
Entrez 2212
HUGO 3616
OMIM 146790
RefSeq NM_021642
UniProt P12318
Other data
Locus Chr. 1 q23
Fc fragment of IgG, low affinity IIb, receptor (CD32)
Crystal structure of the human fcgamma-receptor IIb ectodomain (CD32).[1]
Identifiers
Symbol FCGR2B
Alt. symbols FCG2, FCGR2
Entrez 2213
HUGO 3618
OMIM 604590
RefSeq NM_004001
UniProt P31994
Other data
Locus Chr. 1 q23
Fc fragment of IgG, low affinity IIc, receptor for (CD32)
Identifiers
Symbol FCGR2C
Entrez 9103
HUGO 15626
RefSeq NM_201563
UniProt P31995
Other data
Locus Chr. 1 q23

CD32 is a surface receptor protein and part of a large population of B cell co-receptors, which act to modulate signaling.

It has a low-affinity for IgG antibodies and down-regulates antibody production in the presence of IgG. This feedback loop acts to lower the production of IgG by B cells when there is a surplus in the body. Monoclonal antibodies can distinguish between CD32A and CD32B.[2]

References

  1. ↑ PDB: 2FCB​; Sondermann P, Huber R, Jacob U (March 1999). "Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution". EMBO J. 18 (5): 1095–103. doi:10.1093/emboj/18.5.1095. PMC 1171201. PMID 10064577. ; rendered via PyMOL.
  2. ↑ Veri MC, Gorlatov S, Li H, et al. (2007). "Monoclonal antibodies capable of discriminating the human inhibitory Fcgamma-receptor IIB (CD32B) from the activating Fcgamma-receptor IIA (CD32A): biochemical, biological and functional characterization". Immunology. 121 (3): 392–404. doi:10.1111/j.1365-2567.2007.02588.x. PMC 2265948. PMID 17386079.


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