TAAR6

TAAR6
Identifiers
AliasesTAAR6, TA4, TAR4, TAR6, TRAR4, taR-4, taR-6, trace amine associated receptor 6
External IDsMGI: 2685074 HomoloGene: 27874 GeneCards: TAAR6
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q23.2Start132,570,322 bp[1]
End132,571,359 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

319100

215855

Ensembl

ENSG00000146383

ENSMUSG00000045111

UniProt

Q96RI8

Q5QD13

RefSeq (mRNA)

NM_175067

NM_001010828

RefSeq (protein)

NP_778237

NP_001010828

Location (UCSC)Chr 6: 132.57 – 132.57 MbChr 10: 23.98 – 23.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Trace amine associated receptor 6, also known as TAAR6, is a protein which in humans is encoded by the TAAR6 gene.[5][6]

Function

TAAR6 belongs to the trace amine-associated receptor family. Trace amines are endogenous amine compounds that are chemically similar to classic biogenic amines like dopamine, norepinephrine, serotonin, and histamine. Trace amines were thought to be 'false transmitters' that displace classic biogenic amines from their storage and act on transporters in a fashion similar to the amphetamines, but the identification of brain receptors specific to trace amines indicates that they also have effects of their own.[7][8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000146383 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045111 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C (July 2001). "Trace amines: identification of a family of mammalian G protein-coupled receptors". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 8966–71. doi:10.1073/pnas.151105198. PMC 55357. PMID 11459929.
  6. ↑ Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.
  7. ↑ Duan J, Martinez M, Sanders AR, Hou C, Saitou N, Kitano T, Mowry BJ, Crowe RR, Silverman JM, Levinson DF, Gejman PV (October 2004). "Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia". Am. J. Hum. Genet. 75 (4): 624–38. doi:10.1086/424887. PMC 1182049. PMID 15329799.
  8. ↑ "Entrez Gene: TAAR6 trace amine associated receptor 6".

Further reading

  • Cao Q, Martinez M, Zhang J, et al. (1997). "Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees". Genomics. 43 (1): 1–8. doi:10.1006/geno.1997.4815. PMID 9226366.
  • Kaufmann CA, Suarez B, Malaspina D, et al. (1998). "NIMH Genetics Initiative Millennium Schizophrenia Consortium: linkage analysis of African-American pedigrees". Am. J. Med. Genet. 81 (4): 282–9. doi:10.1002/(SICI)1096-8628(19980710)81:4<282::AID-AJMG2>3.0.CO;2-W. PMID 9674972.
  • Borowsky B, Adham N, Jones KA, et al. (2001). "Trace amines: identification of a family of mammalian G protein-coupled receptors". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 8966–71. doi:10.1073/pnas.151105198. PMC 55357. PMID 11459929.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
  • Duan J, Martinez M, Sanders AR, et al. (2004). "Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia". Am. J. Hum. Genet. 75 (4): 624–38. doi:10.1086/424887. PMC 1182049. PMID 15329799.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Lindemann L, Ebeling M, Kratochwil NA, et al. (2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.
  • Amann D, Avidan N, Kanyas K, et al. (2006). "The trace amine receptor 4 gene is not associated with schizophrenia in a sample linked to chromosome 6q23". Mol. Psychiatry. 11 (2): 119–21. doi:10.1038/sj.mp.4001752. PMID 16189505.

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