Neuropeptide Y receptor Y1

NPY1R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2F1U, 2IIL
Identifiers
Aliases	NPY1R, NPY1-R, NPYR, Neuropeptide Y receptor Y1
External IDs	MGI: 104963 HomoloGene: 700 GeneCards: NPY1R
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	163,344,832 bp[1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[2]
End	66,706,792 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• neuropeptide Y receptor activity; • G-protein coupled receptor activity; • signal transducer activity; • protein binding; • peptide YY receptor activity; • pancreatic polypeptide receptor activity;
Cellular component	• integral component of membrane; • membrane; • plasma membrane; • integral component of plasma membrane;
Biological process	• adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; • locomotory behavior; • regulation of multicellular organism growth; • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; • outflow tract morphogenesis; • blood circulation; • regulation of blood pressure; • feeding behavior; • glucose metabolic process; • nociception; • neuropeptide signaling pathway; • signal transduction; • chemical synaptic transmission; • G-protein coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4886
	18166
	ENSG00000164128
	ENSMUSG00000036437
	P25929
	Q04573
	NM_000909
	NM_010934; NM_001358955
	NP_000900
	NP_035064; NP_001345884
	Wikidata
View/Edit Human	View/Edit Mouse

Neuropeptide Y receptor type 1 is a protein that in humans is encoded by the NPY1R gene.^[5]^[6]

Selective ligands

Agonists

Neuropeptide Y (endogenous agonist, non subtype selective)
Peptide YY

Antagonists

Peptide

BVD-10 (selective NPY₁ antagonist, CAS# 262418-00-8)
GR-231,118 (mixed NPY₁ antagonist / NPY₄ agonist, CAS# 158859-98-4)

Non-peptide

BIBO-3304 (CAS# 191868-14-1)
BIBP-3226 (CAS# 159013-54-4)
PD-160,170 (CAS# 181468-88-2)

Available Structures

5ZBH (Neuropeptide Y1 bound to antagonist BMS-193835)^[7]
5ZBQ (Neuropeptide Y1 bound to antagonist UR-MK299)^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164128 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036437 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Herzog H, Baumgartner M, Vivero C, Selbie LA, Auer B, Shine J (March 1993). "Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor". The Journal of Biological Chemistry. 268 (9): 6703–7. PMID 8095935.
↑ "Entrez Gene: NPY1R neuropeptide Y receptor Y1".
1 2 Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B (April 2018). "1 receptor". Nature. 556 (7702): 520–524. doi:10.1038/s41586-018-0046-x. PMC 5920736. PMID 29670288.

Wan CP, Lau BH (February 1995). "Neuropeptide Y receptor subtypes". Life Sciences. 56 (13): 1055–64. doi:10.1016/0024-3205(95)00041-4. PMID 9001438.
Parker E, Van Heek M, Stamford A (April 2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology. 440 (2–3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534.
Bettio A, Beck-Sickinger AG (2002). "Biophysical methods to study ligand-receptor interactions of neuropeptide Y". Biopolymers. 60 (6): 420–37. doi:10.1002/1097-0282(2001)60:6<420::AID-BIP10183>3.0.CO;2-W. PMID 12209475.
Larhammar D, Blomqvist AG, Yee F, Jazin E, Yoo H, Wahlested C (June 1992). "Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type". The Journal of Biological Chemistry. 267 (16): 10935–8. PMID 1317848.
Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA (July 1992). "Cloned human neuropeptide Y receptor couples to two different second messenger systems". Proceedings of the National Academy of Sciences of the United States of America. 89 (13): 5794–8. doi:10.1073/pnas.89.13.5794. PMC 402104. PMID 1321422.
Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R (September 1995). "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor". The Journal of Biological Chemistry. 270 (39): 22661–4. doi:10.1074/jbc.270.39.22661. PMID 7559383.
Gicquiaux H, Lecat S, Gaire M, Dieterlen A, Mély Y, Takeda K, Bucher B, Galzi JL (February 2002). "Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor". The Journal of Biological Chemistry. 277 (8): 6645–55. doi:10.1074/jbc.M107224200. PMID 11741903.
Sheriff S, F Qureshy A, T Chance W, Kasckow JW, Balasubramaniam A (January 2002). "Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected]". Peptides. 23 (1): 87–96. doi:10.1016/S0196-9781(01)00583-6. PMID 11814622.
Cox HM, Tough IR (March 2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". British Journal of Pharmacology. 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMC 1573267. PMID 11906964.
Uddman R, Möller S, Nilsson T, Nyström S, Ekstrand J, Edvinsson L (May 2002). "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues". Peptides. 23 (5): 927–34. doi:10.1016/S0196-9781(02)00003-7. PMID 12084524.
Cantó Soler MV, Gallo JE, Dodds RA, Hökfelt T, Villar MJ, Suburo AM (September 2002). "Y1 receptor of neuropeptide Y as a glial marker in proliferative vitreoretinopathy and diseased human retina". Glia. 39 (3): 320–4. doi:10.1002/glia.10107. PMID 12203398.
Berglund MM, Schober DA, Statnick MA, McDonald PH, Gehlert DR (July 2003). "The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction". The Journal of Pharmacology and Experimental Therapeutics. 306 (1): 147–56. doi:10.1124/jpet.103.051227. PMID 12665544.
Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Körner M, Waser B, Reubi JC (December 2004). "High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia". Clinical Cancer Research. 10 (24): 8426–33. doi:10.1158/1078-0432.CCR-04-0821. PMID 15623622.

External links

"Neuropeptide Y Receptors: Y₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164128 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036437 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid8095935-5] Herzog H, Baumgartner M, Vivero C, Selbie LA, Auer B, Shine J (March 1993). "Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor". The Journal of Biological Chemistry. 268 (9): 6703–7. PMID 8095935.

[entrez-6] "Entrez Gene: NPY1R neuropeptide Y receptor Y1".

[:0-7] 1 2 Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B (April 2018). "1 receptor". Nature. 556 (7702): 520–524. doi:10.1038/s41586-018-0046-x. PMC 5920736. PMID 29670288.