GPR34

GPR34
Identifiers
AliasesGPR34, LYPSR1, G protein-coupled receptor 34
External IDsMGI: 1346334 HomoloGene: 36174 GeneCards: GPR34
Gene location (Human)
Chr.X chromosome (human)[1]
BandXp11.4Start41,688,973 bp[1]
End41,697,277 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

2857

23890

Ensembl

ENSG00000171659

ENSMUSG00000040229

UniProt

Q9UPC5

Q9R1K6

RefSeq (mRNA)

NM_001033513
NM_001033514
NM_001097579
NM_005300

NM_011823

RefSeq (protein)

NP_001091048
NP_005291

NP_035953

Location (UCSC)Chr X: 41.69 – 41.7 MbChr X: 13.63 – 13.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable G-protein coupled receptor 34 is a protein that in humans is encoded by the GPR34 gene.[5][6][7]

Function

G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM][7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000171659 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040229 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Schöneberg T, Schulz A, Grosse R, Schade R, Henklein P, Schultz G, Gudermann T (July 1999). "A novel subgroup of class I G-protein-coupled receptors". Biochimica et Biophysica Acta. 1446 (1–2): 57–70. doi:10.1016/s0167-4781(99)00081-0. PMID 10395919.
  6. ↑ Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF (February 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno.1998.5655. PMID 10036181.
  7. 1 2 "Entrez Gene: GPR34 G protein-coupled receptor 34".

Further reading

  • Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (September 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
  • Jacobi FK, Broghammer M, Pesch K, Zrenner E, Berger W, Meindl A, Pusch CM (July 2000). "Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1". Human Genetics. 107 (1): 89–91. doi:10.1007/s004390050017. PMID 10982042.
  • Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Engemaier E, Römpler H, Schöneberg T, Schulz A (February 2006). "Genomic and supragenomic structure of the nucleotide-like G-protein-coupled receptor GPR34". Genomics. 87 (2): 254–64. doi:10.1016/j.ygeno.2005.10.001. PMID 16338117.
  • Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (December 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
  • Liebscher I, Müller U, Teupser D, Engemaier E, Engel KM, Ritscher L, Thor D, Sangkuhl K, Ricken A, Wurm A, Piehler D, Schmutzler S, Fuhrmann H, Albert FW, Reichenbach A, Thiery J, Schöneberg T, Schulz A (January 2011). "Altered immune response in mice deficient for the G protein-coupled receptor GPR34". The Journal of Biological Chemistry. 286 (3): 2101–10. doi:10.1074/jbc.M110.196659. PMC 3023507. PMID 21097509.
  • Ritscher L, Engemaier E, Stäubert C, Liebscher I, Schmidt P, Hermsdorf T, Römpler H, Schulz A, Schöneberg T (May 2012). "The ligand specificity of the G-protein-coupled receptor GPR34". The Biochemical Journal. 443 (3): 841–50. doi:10.1042/BJ20112090. PMID 22348703.
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