CLEC10A

CLEC10A
Identifiers
AliasesCLEC10A, CD301, CLECSF13, CLECSF14, HML, HML2, MGL, C-type lectin domain family 10 member A, C-type lectin domain containing 10A
External IDsMGI: 96975 HomoloGene: 7836 GeneCards: CLEC10A
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17p13.1Start7,074,537 bp[1]
End7,080,307 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

10462

17312

Ensembl

ENSG00000132514

ENSMUSG00000000318

UniProt

Q8IUN9

P49300

RefSeq (mRNA)

NM_006344
NM_182906
NM_001330070

NM_001204252
NM_010796

RefSeq (protein)

NP_001316999
NP_006335
NP_878910

NP_001191181
NP_034926

Location (UCSC)Chr 17: 7.07 – 7.08 MbChr 11: 70.16 – 70.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

C-type lectin domain family 10 member A also known as CLEC10A is a protein that in humans is encoded by the CLEC10A gene.[5]

Function

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000132514 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000318 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Suzuki N, Yamamoto K, Toyoshima S, Osawa T, Irimura T (January 1996). "Molecular cloning and expression of cDNA encoding human macrophage C-type lectin. Its unique carbohydrate binding specificity for Tn antigen". J. Immunol. 156 (1): 128–35. PMID 8598452.
  6. ↑ "Entrez Gene: CLEC10A C-type lectin domain family 10, member A".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • van Vliet SJ, Steeghs L, Bruijns SC, et al. (2009). Seifert HS, ed. "Variation of Neisseria gonorrhoeae Lipooligosaccharide Directs Dendritic Cell–Induced T Helper Responses". PLoS Pathog. 5 (10): e1000625. doi:10.1371/journal.ppat.1000625. PMC 2757725. PMID 19834553.
  • Iijima M, Tomita M, Morozumi S, et al. (2009). "Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP". Neurology. 73 (17): 1348–52. doi:10.1212/WNL.0b013e3181bd1139. PMID 19776380.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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