TRPM3

TRPM3
Identifiers
AliasesTRPM3, GON-2, LTRPC3, MLSN2, transient receptor potential cation channel subfamily M member 3
External IDsMGI: 2443101 HomoloGene: 62287 GeneCards: TRPM3
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q21.12-q21.13Start70,529,063 bp[1]
End71,446,904 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

80036

226025

Ensembl

ENSG00000083067

ENSMUSG00000052387

UniProt

Q9HCF6

n/a

RefSeq (mRNA)
RefSeq (protein)

n/a

Location (UCSC)Chr 9: 70.53 – 71.45 MbChr 19: 22.14 – 22.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transient receptor potential cation channel subfamily M member 3 is a protein that in humans is encoded by the TRPM3 gene.[5]

The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been -identified.[6] TRPM3 was shown to be activated by the neurosteroid pregnenolone sulphate in pancreatic beta cell. The activation causes calcium influx and subsequent insulin release, therefore it is suggested that TRPM3 modulates glucose homeostasis.[7]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000083067 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052387 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Clapham DE, Julius D, Montell C, Schultz G (Dec 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.
  6. ↑ "Entrez Gene: TRPM3 transient receptor potential cation channel, subfamily M, member 3".
  7. ↑ Wagner TF, Loch S, Lambert S, et al. (November 2008). "Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells". Nature Cell Biology. 10 (12): 1421–30. doi:10.1038/ncb1801. PMID 18978782.

Further reading

  • Oberwinkler J, Phillipp SE (2007). "TRPM3". Handb Exp Pharmacol. 179 (179): 253–67. doi:10.1007/978-3-540-34891-7_15. PMID 17217062.
  • Harteneck C, Reiter B (2007). "TRP channels activated by extracellular hypo-osmoticity in epithelia". Biochem. Soc. Trans. 35 (Pt 1): 91–5. doi:10.1042/BST0350091. PMID 17233610.
  • Held, K; Voets, T; Vriens, J (2014). "TRPM3 in temperature sensing and beyond". Temperature (Austin, Tex.). 2 (2): 201–13. doi:10.4161/23328940.2014.988524. PMC 4844244. PMID 27227024.
  • Islam, Md. Shahidul, ed. (2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology. 704. New York: Springer Science+Business Media. doi:10.1007/978-94-007-0265-3. ISBN 978-94-007-0265-3. ISSN 2214-8019. OCLC 710148029.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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