SCN4B

SCN4B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4MZ2, 4MZ3
Identifiers
Aliases	SCN4B, ATFB17, LQT10, Navbeta4, sodium voltage-gated channel beta subunit 4
External IDs	OMIM: 608256 MGI: 2687406 HomoloGene: 18384 GeneCards: SCN4B
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	118,152,888 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	45,154,152 bp[2]
Gene ontology
Molecular function	• sodium channel regulator activity; • ion channel binding; • sodium channel activity; • voltage-gated ion channel activity; • voltage-gated sodium channel activity involved in cardiac muscle cell action potential; • voltage-gated sodium channel activity;
Cellular component	• voltage-gated sodium channel complex; • integral component of membrane; • membrane; • intercalated disc; • intrinsic component of plasma membrane; • plasma membrane;
Biological process	• cardiac muscle contraction; • sodium ion transmembrane transport; • sodium ion transport; • regulation of ion transmembrane transport; • cardiac muscle cell action potential involved in contraction; • ion transport; • regulation of sodium ion transmembrane transporter activity; • positive regulation of sodium ion transport; • AV node cell action potential; • regulation of heart rate by cardiac conduction; • membrane depolarization during cardiac muscle cell action potential; • regulation of ventricular cardiac muscle cell membrane repolarization;
	Sources:Amigo / QuickGO
Orthologs
	6330
	399548
	ENSG00000177098
	ENSMUSG00000046480
	Q8IWT1
	Q7M729
	NM_001142348; NM_001142349; NM_174934
	NM_001013390
	NP_001135820; NP_001135821; NP_777594
	NP_001013408
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium channel β-subunit 4, also known as SCN4B or Naβ4, is an auxiliary sodium channel subunit that can alter the kinetics of sodium channels.^[5] The protein is encoded by the SCN4B gene.^[6] Mutations in the SCN4B are associated with long QT syndrome.^[7]

SCN4B might additionally function as a cell adhesion molecule.^[8]^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000177098 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046480 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Lewis, Amanda H.; Raman, Indira M. (2014-11-15). "Resurgent current of voltage-gated Na+ channels". The Journal of Physiology. 592 (22): 4825–4838. doi:10.1113/jphysiol.2014.277582. ISSN 1469-7793. PMC 4259529. PMID 25172941.
↑ "Entrez Gene: sodium channel".
↑ Medeiros-Domingo A, Kaku T, Tester DJ, Iturralde-Torres P, Itty A, Ye B, Valdivia C, Ueda K, Canizales-Quinteros S, Tusié-Luna MT, Makielski JC, Ackerman MJ (July 2007). "SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome". Circulation. 116 (2): 134–42. doi:10.1161/CIRCULATIONAHA.106.659086. PMC 3332546. PMID 17592081.
↑ Shimizu, Hideaki (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports. 6: 26618. doi:10.1038/srep26618.
↑ Shimizu, Hideaki (2017). "Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion". J Biol Chem. 27. doi:10.1074/jbc.M117.786509.

Delgado P, GarcÃa-Zueco JC, Rubio-Félix D, Giralt M (1992). "[Idiopathic thrombocytopenic purpura: present knowledge and future expectations]". Sangre. 37 (6): 449–56. PMID 1293796.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Yu FH, Westenbroek RE, Silos-Santiago I, et al. (2003). "Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2". J. Neurosci. 23 (20): 7577–85. PMID 12930796.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Webb J, Wu FF, Cannon SC (2009). "Slow inactivation of the NaV1.4 sodium channel in mammalian cells is impeded by co-expression of the beta1 subunit". Pflügers Arch. 457 (6): 1253–63. doi:10.1007/s00424-008-0600-8. PMID 18941776.
Shimizu, Hideaki (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports. 6: 26618. doi:10.1038/srep26618.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000177098 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046480 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[5] Lewis, Amanda H.; Raman, Indira M. (2014-11-15). "Resurgent current of voltage-gated Na+ channels". The Journal of Physiology. 592 (22): 4825–4838. doi:10.1113/jphysiol.2014.277582. ISSN 1469-7793. PMC 4259529. PMID 25172941.

[entrez-6] "Entrez Gene: sodium channel".

[pmid17592081-7] Medeiros-Domingo A, Kaku T, Tester DJ, Iturralde-Torres P, Itty A, Ye B, Valdivia C, Ueda K, Canizales-Quinteros S, Tusié-Luna MT, Makielski JC, Ackerman MJ (July 2007). "SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome". Circulation. 116 (2): 134–42. doi:10.1161/CIRCULATIONAHA.106.659086. PMC 3332546. PMID 17592081.

[pmid27216889-8] Shimizu, Hideaki (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports. 6: 26618. doi:10.1038/srep26618.

[pmid28655765-9] Shimizu, Hideaki (2017). "Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion". J Biol Chem. 27. doi:10.1074/jbc.M117.786509.

SCN4B

See also

References