TRPM4

TRPM4
Identifiers
AliasesTRPM4, PFHB1B, TRPM4B, LTrpC4, htransient receptor potential cation channel subfamily M member 4
External IDsOMIM: 606936 MGI: 1915917 HomoloGene: 23033 GeneCards: TRPM4
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.33Start49,157,741 bp[1]
End49,211,836 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

54795

68667

Ensembl

ENSG00000130529

ENSMUSG00000038260

UniProt

Q8TD43

Q7TN37

RefSeq (mRNA)

NM_175130

RefSeq (protein)

NP_780339

Location (UCSC)Chr 19: 49.16 – 49.21 MbChr 7: 45.3 – 45.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transient receptor potential cation channel subfamily M member 4 (hTRPM4), also known as melastatin-4, is a protein that in humans is encoded by the TRPM4 gene.[5][6]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000130529 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038260 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Xu XZ, Moebius F, Gill DL, Montell C (September 2001). "Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform". Proc. Natl. Acad. Sci. U.S.A. 98 (19): 10692–7. doi:10.1073/pnas.191360198. PMC 58528. PMID 11535825.
  6. ↑ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.

Further reading

  • Islam, Md. Shahidul (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology. 704. Berlin: Springer. p. 700. ISBN 978-94-007-0264-6.
  • Launay P, Fleig A, Perraud AL, Scharenberg AM, Penner R, Kinet JP (2002). "TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization". Cell. 109 (3): 397–407. doi:10.1016/S0092-8674(02)00719-5. PMID 12015988.
  • Launay P, Cheng H, Srivatsan S, Penner R, Fleig A, Kinet JP (2004). "TRPM4 regulates calcium oscillations after T cell activation". Science. 306 (5700): 1374–1377. doi:10.1126/science.1098845. PMID 15550671.
  • Vennekens R, Nilius B (2007). "Insights into TRPM4 function, regulation and physiological role". Handb Exp Pharmacol. Handbook of Experimental Pharmacology. 179 (179): 269–85. doi:10.1007/978-3-540-34891-7_16. ISBN 978-3-540-34889-4. PMID 17217063.
  • Vennekens R, Olausson J, Meissner M, Bloch W, Mathar I, Philipp SE, Schmitz F, Weissgerber P, Nilius B, Flockerzi V, Freichel M (2007). "Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4". Nat Immunol. 8 (3): 312–320. doi:10.1038/ni1441. PMID 17293867.
  • Barbet G, Demion M, Moura IC, Serafini N, Léger T, Vrtovsnik F, Monteiro RC, Guinamard R, Kinet JP, Launay P (2008). "The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells". Nat Immunol. 9 (10): 1148–56. doi:10.1038/ni.1648. PMC 2956271. PMID 18758465.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.