KCNK7

KCNK7
Identifiers
AliasesKCNK7, K2p7.1, TWIK3, potassium two pore domain channel subfamily K member 7
External IDsMGI: 1341841 HomoloGene: 43131 GeneCards: KCNK7
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.1Start65,592,855 bp[1]
End65,595,996 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

10089

16530

Ensembl

ENSG00000173338

ENSMUSG00000024936

UniProt

Q9Y2U2

Q9Z2T1

RefSeq (mRNA)

NM_033456
NM_005714
NM_033347
NM_033348
NM_033455

NM_001004138
NM_010609

RefSeq (protein)

NP_005705
NP_203133
NP_203134
NP_258416

NP_034739

Location (UCSC)Chr 11: 65.59 – 65.6 MbChr 19: 5.7 – 5.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium channel, subfamily K, member 7, also known as KCNK7 or K2P7.1 is a protein which in humans is encoded by the KCNK7 gene. K2P7.1 is a potassium channel containing two pore-forming P domains.[5][6][7] Multiple transcript variants encoding different isoforms have been found for this gene.[8]

Function

This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; It may require other non-pore-forming proteins for activity.[8]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000173338 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024936 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G, Lazdunski M (April 1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure". J. Biol. Chem. 274 (17): 11751–60. doi:10.1074/jbc.274.17.11751. PMID 10206991.
  6. ↑ Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (March 2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078.
  7. ↑ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.
  8. 1 2 "Entrez Gene: potassium channel".

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078.
  • Salinas M, Reyes R, Lesage F, et al. (1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure". J. Biol. Chem. 274 (17): 11751–60. doi:10.1074/jbc.274.17.11751. PMID 10206991.
  • Medhurst AD, Rennie G, Chapman CG, et al. (2001). "Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery". Brain Res. Mol. Brain Res. 86 (1–2): 101–14. doi:10.1016/S0169-328X(00)00263-1. PMID 11165377.


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