KCNJ14

KCNJ14
Identifiers
AliasesKCNJ14, IRK4, KIR2.4, potassium voltage-gated channel subfamily J member 14
External IDsMGI: 2384820 HomoloGene: 27086 GeneCards: KCNJ14
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.33Start48,455,509 bp[1]
End48,466,980 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3770

211480

Ensembl

ENSG00000182324

ENSMUSG00000058743

UniProt

Q9UNX9

Q8JZN3

RefSeq (mRNA)

NM_170720
NM_013348

NM_145963

RefSeq (protein)

NP_037480

NP_666075

Location (UCSC)Chr 19: 48.46 – 48.47 MbChr 7: 45.82 – 45.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium inwardly-rectifying channel, subfamily J, member 14 (KCNJ14), also known as Kir2.4, is a human gene.[5]

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. Two transcript variants encoding the same protein have been found for this gene.[5]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000182324 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000058743 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: KCNJ14 potassium inwardly-rectifying channel, subfamily J, member 14".

Further reading

  • Kubo Y, Adelman JP, Clapham DE, et al. (2006). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Töpert C, Döring F, Wischmeyer E, et al. (1998). "Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei". J. Neurosci. 18 (11): 4096–105. PMID 9592090.
  • Töpert C, Döring F, Derst C, et al. (2000). "Cloning, structure and assignment to chromosome 19q13 of the human Kir2.4 inwardly rectifying potassium channel gene (KCNJ14)". Mamm. Genome. 11 (3): 247–9. doi:10.1007/s003350010047. PMID 10723734.
  • Hughes BA, Kumar G, Yuan Y, et al. (2000). "Cloning and functional expression of human retinal kir2.4, a pH-sensitive inwardly rectifying K(+) channel". Am. J. Physiol., Cell Physiol. 279 (3): C771–84. PMID 10942728.
  • Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Fang Y, Schram G, Romanenko VG, et al. (2005). "Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2". Am. J. Physiol., Cell Physiol. 289 (5): C1134–44. doi:10.1152/ajpcell.00077.2005. PMID 15958527.
  • Tennant BP, Cui Y, Tinker A, Clapp LH (2007). "Functional expression of inward rectifier potassium channels in cultured human pulmonary smooth muscle cells: evidence for a major role of Kir2.4 subunits". J. Membr. Biol. 213 (1): 19–29. doi:10.1007/s00232-006-0037-y. PMC 1973150. PMID 17347781.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.