KCNK10

KCNK10
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesKCNK10, K2p10.1, PPP1R97, TREK-2, TREK2, potassium two pore domain channel subfamily K member 10
External IDsMGI: 1919508 HomoloGene: 11321 GeneCards: KCNK10
Gene location (Human)
Chr.Chromosome 14 (human)[1]
Band14q31.3Start88,180,103 bp[1]
End88,326,907 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

54207

72258

Ensembl

ENSG00000100433

ENSMUSG00000033854

UniProt

P57789

n/a

RefSeq (mRNA)

NM_021161
NM_138317
NM_138318

NM_029911
NM_001316664
NM_001316665
NM_001316666

RefSeq (protein)

NP_066984
NP_612190
NP_612191

n/a

Location (UCSC)Chr 14: 88.18 – 88.33 MbChr 12: 98.43 – 98.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium channel, subfamily K, member 10, also known as KCNK10 is a human gene. The protein encoded by this gene, K2P10.1, is a potassium channel containing two pore-forming P domains.[5][6][7]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000100433 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033854 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Lesage F, Terrenoire C, Romey G, Lazdunski M (September 2000). "Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors". The Journal of Biological Chemistry. 275 (37): 28398–405. doi:10.1074/jbc.M002822200. PMID 10880510.
  6. ↑ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacological Reviews. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.
  7. ↑ Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, Sansom MS, Tucker SJ, Carpenter EP (March 2015). "K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac". Science. 347 (6227): 1256–9. doi:10.1126/science.1261512. PMID 25766236.

Further reading

  • Gu W, Schlichthörl G, Hirsch JR, Engels H, Karschin C, Karschin A, Derst C, Steinlein OK, Daut J (March 2002). "Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2". The Journal of Physiology. 539 (Pt 3): 657–68. doi:10.1113/jphysiol.2001.013432. PMC 2290188. PMID 11897838.
  • Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (March 2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nature Reviews. Neuroscience. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078.
  • Gierten J, Ficker E, Bloehs R, Schlömer K, Kathöfer S, Scholz E, Zitron E, Kiesecker C, Bauer A, Becker R, Katus HA, Karle CA, Thomas D (August 2008). "Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein". British Journal of Pharmacology. 154 (8): 1680–90. doi:10.1038/bjp.2008.213. PMC 2518462. PMID 18516069.
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Huang D, Yu B (2008). "Recent advance and possible future in TREK-2: a two-pore potassium channel may involved in the process of NPP, brain ischemia and memory impairment". Medical Hypotheses. 70 (3): 618–24. doi:10.1016/j.mehy.2007.06.016. PMID 17689202.
  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Bang H, Kim Y, Kim D (June 2000). "TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family". The Journal of Biological Chemistry. 275 (23): 17412–9. doi:10.1074/jbc.M000445200. PMID 10747911.
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