KCNK16

KCNK16
Identifiers
AliasesKCNK16, K2p16.1, TALK-1, TALK1, potassium two pore domain channel subfamily K member 16
External IDsMGI: 1921821 HomoloGene: 75328 GeneCards: KCNK16
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p21.2Start39,314,698 bp[1]
End39,322,968 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

83795

74571

Ensembl

ENSG00000095981

ENSMUSG00000023387

UniProt

Q96T55

G5E845

RefSeq (mRNA)

NM_001135105
NM_001135106
NM_001135107
NM_032115
NM_001363784

NM_029006

RefSeq (protein)

NP_001128577
NP_001128578
NP_001128579
NP_115491
NP_001350713

NP_083282

Location (UCSC)Chr 6: 39.31 – 39.32 MbChr 14: 20.26 – 20.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium channel subfamily K member 16 is a protein that in humans is encoded by the KCNK16 gene.[5][6] The protein encoded by this gene, K2P16.1, is a potassium channel containing two pore-forming P domains.[5][6]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000095981 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023387 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F (Mar 2001). "Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels". Biochem Biophys Res Commun. 282 (1): 249–56. doi:10.1006/bbrc.2001.4562. PMID 11263999.
  6. 1 2 Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.

Further reading

  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078.
  • Han J, Kang D, Kim D (2003). "Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1". Am. J. Physiol., Cell Physiol. 285 (3): C529–38. doi:10.1152/ajpcell.00601.2002. PMID 12724142.
  • Gierten J, Ficker E, Bloehs R, et al. (2008). "Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein". Br. J. Pharmacol. 154 (8): 1680–90. doi:10.1038/bjp.2008.213. PMC 2518462. PMID 18516069.


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