GJD4

GJD4
Identifiers
AliasesGJD4, CX40.1, gap junction protein delta 4
External IDsMGI: 2444990 HomoloGene: 17692 GeneCards: GJD4
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10p11.21Start35,605,410 bp[1]
End35,608,935 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

219770

225152

Ensembl

ENSG00000177291

ENSMUSG00000036855

UniProt

Q96KN9

Q8BSD4

RefSeq (mRNA)

NM_153368

NM_153086

RefSeq (protein)

NP_699199

NP_694726

Location (UCSC)Chr 10: 35.61 – 35.61 MbChr 18: 9.28 – 9.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gap junction delta-4 protein (GJD4), also known as connexin-40.1 (Cx40.1), is a protein that in humans is encoded by the GJD4 gene.[5]

Function

Connexins, such as GJD4, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits.[5][6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000177291 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036855 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: gap junction protein".
  6. ↑ Söhl G, Nielsen PA, Eiberger J, Willecke K (2003). "Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues". Cell Commun. Adhes. 10 (1): 27–36. doi:10.1080/15419060302063. PMID 12881038.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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