KCNB2

KCNB2
Identifiers
AliasesKCNB2, KV2.2, potassium voltage-gated channel subfamily B member 2
External IDsMGI: 99632 HomoloGene: 31263 GeneCards: KCNB2
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q21.11Start72,537,391 bp[1]
End72,938,349 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

9312

98741

Ensembl

ENSG00000182674

ENSMUSG00000092083

UniProt

Q92953

A6H8H5

RefSeq (mRNA)

NM_004770

NM_001033195
NM_001098528

RefSeq (protein)

NP_004761

NP_001091998

Location (UCSC)Chr 8: 72.54 – 72.94 MbChr 1: 15.29 – 15.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium voltage-gated channel subfamily B member 2 is a protein that in humans is encoded by the KCNB2 gene.[5][6] The protein encoded by this gene is a voltage-gated potassium channel subunit.[5][6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000182674 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000092083 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 Schmalz F, Kinsella J, Koh SD, Vogalis F, Schneider A, Flynn ER, Kenyon JL, Horowitz B (Jul 1998). "Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles". Am J Physiol. 274 (5 Pt 1): G901–11. PMID 9612272.
  6. 1 2 Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.

Further reading

  • Nyholt DR, LaForge KS, Kallela M, et al. (2008). "A high-density association screen of 155 ion transport genes for involvement with common migraine". Hum. Mol. Genet. 17 (21): 3318–31. doi:10.1093/hmg/ddn227. PMC 2566523. PMID 18676988.
  • Yan L, Figueroa DJ, Austin CP, et al. (2004). "Expression of voltage-gated potassium channels in human and rhesus pancreatic islets". Diabetes. 53 (3): 597–607. doi:10.2337/diabetes.53.3.597. PMID 14988243.
  • Hugnot JP, Salinas M, Lesage F, et al. (1996). "Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels". EMBO J. 15 (13): 3322–31. PMC 451895. PMID 8670833.
  • Baranzini SE, Wang J, Gibson RA, et al. (2009). "Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis". Hum. Mol. Genet. 18 (4): 767–78. doi:10.1093/hmg/ddn388. PMID 19010793.
  • Vasan RS, Larson MG, Aragam J, et al. (2007). "Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study". BMC Med. Genet. 8 Suppl 1: S2. doi:10.1186/1471-2350-8-S1-S2. PMC 1995617. PMID 17903301.
  • Wu C, Ma MH, Brown KR, et al. (2007). "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening". Proteomics. 7 (11): 1775–85. doi:10.1002/pmic.200601006. PMID 17474147.
  • Salinas M, de Weille J, Guillemare E, et al. (1997). "Modes of regulation of shab K+ channel activity by the Kv8.1 subunit". J. Biol. Chem. 272 (13): 8774–80. doi:10.1074/jbc.272.13.8774. PMID 9079713.


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