Two-pore-domain potassium channel

The two-pore-domain potassium channel is a family of 15 members that form what is known as "leak channels" which possess Goldman-Hodgkin-Katz (open) rectification.[1] These channels are regulated by several mechanisms including oxygen tension, pH, mechanical stretch, and G-proteins . Their name is derived from the fact that the α subunits consist of four transmembrane segments, each containing two pore loops. As such, they structurally correspond to two inward-rectifier α subunits and thus form dimers in the membrane.

Below is a list of the 15 known two-pore-domain human potassium channels:[1]

GeneChannel[2]FamilyAliases
KCNK1K2p1.1TWIK[3][4]TWIK-1
KCNK2K2p2.1TREK[3][4]TREK-1
KCNK3K2p3.1TASK[3][4]TASK-1
KCNK4K2p4.1TREK[3][4]TRAAK[5]
KCNK5K2p5.1TASK[3][4]TASK-2[6]
KCNK6K2p6.1TWIK[3][4]TWIK-2
KCNK7K2p7.1TWIK[3][4]
KCNK9K2p9.1TASK[3][4]TASK-3
KCNK10K2p10.1TREK[3][4]TREK-2
KCNK12K2p12.1THIKTHIK-2
KCNK13K2p13.1THIKTHIK-1
KCNK15K2p15.1TASK[3][4]TASK-5
KCNK16K2p16.1TALK[3][4]TALK-1
KCNK17K2p17.1TALK[3][4]TALK-2, TASK-4
KCNK18K2p18.1TRIK, TRESK[3][4][7][8]

See also

References

  1. 1 2 Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacological Reviews. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.
  2. ↑ Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, et al. (Dec 2003). "International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels". Pharmacological Reviews. 55 (4): 583–6. doi:10.1124/pr.55.4.9. PMID 14657415.
  3. 1 2 3 4 5 6 7 8 9 10 11 12 13 Enyedi P, Czirják G (Apr 2010). "Molecular background of leak K+ currents: two-pore domain potassium channels". Physiological Reviews. 90 (2): 559–605. doi:10.1152/physrev.00029.2009. PMID 20393194.
  4. 1 2 3 4 5 6 7 8 9 10 11 12 13 Lotshaw DP (2007). "Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels". Cell Biochemistry and Biophysics. 47 (2): 209–56. doi:10.1007/s12013-007-0007-8. PMID 17652773.
  5. ↑ Fink M, Lesage F, Duprat F, Heurteaux C, Reyes R, Fosset M, Lazdunski M (Jun 1998). "A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids". The EMBO Journal. 17 (12): 3297–308. doi:10.1093/emboj/17.12.3297. PMC 1170668. PMID 9628867.
  6. ↑ Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (Mar 2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nature Reviews. Neuroscience. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078.
  7. ↑ Sano Y, Inamura K, Miyake A, Mochizuki S, Kitada C, Yokoi H, Nozawa K, Okada H, Matsushime H, Furuichi K (Jul 2003). "A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord". The Journal of Biological Chemistry. 278 (30): 27406–12. doi:10.1074/jbc.M206810200. PMID 12754259.
  8. ↑ Czirják G, Tóth ZE, Enyedi P (Apr 2004). "The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin". The Journal of Biological Chemistry. 279 (18): 18550–8. doi:10.1074/jbc.M312229200. PMID 14981085.
  • Tandem+Pore+Domain+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
  • "Two-P Potassium Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.


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