CLCC1

CLCC1
Identifiers
AliasesCLCC1, MCLC, chloride channel CLIC like 1
External IDsMGI: 2385186 HomoloGene: 9032 GeneCards: CLCC1
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p13.3Start108,929,508 bp[1]
End108,963,457 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

23155

229725

Ensembl

ENSG00000121940

ENSMUSG00000027884

UniProt

Q96S66

Q99LI2

RefSeq (mRNA)

NM_015127
NM_001048210
NM_001278202
NM_001278203

NM_001177770
NM_001177771
NM_145543
NM_001355632

RefSeq (protein)

NP_001041675
NP_001265131
NP_001265132
NP_055942

NP_001171241
NP_001171242
NP_663518
NP_001342561

Location (UCSC)Chr 1: 108.93 – 108.96 MbChr 3: 108.65 – 108.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chloride channel CLIC-like 1 also known as CLCC1 is a human gene.[5][6]

The protein encoded by this gene is a chloride channel which is related in sequence to the S. cerevisiae MID-1 stretch-activated channel. CLCC1 is located in the membranes of intracellular compartments including endoplasmic reticulum and the Golgi apparatus. It is highly expressed in the testis and moderately in the spleen, liver, kidney, heart, brain, and lung.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000121940 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027884 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  6. 1 2 Nagasawa M, Kanzaki M, Iino Y, Morishita Y, Kojima I (June 2001). "Identification of a novel chloride channel expressed in the endoplasmic reticulum, golgi apparatus, and nucleus". J. Biol. Chem. 276 (23): 20413–8. doi:10.1074/jbc.M100366200. PMID 11279057.

Further reading

  • Nagase T, Ishikawa K, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Nagasawa M, Kanzaki M, Iino Y, et al. (2001). "Identification of a novel chloride channel expressed in the endoplasmic reticulum, golgi apparatus, and nucleus". J. Biol. Chem. 276 (23): 20413–8. doi:10.1074/jbc.M100366200. PMID 11279057.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.


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