ZEB1

ZEB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E19
Identifiers
Aliases	ZEB1, zinc finger E-box binding homeobox 1, AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
External IDs	OMIM: 189909 MGI: 1344313 HomoloGene: 31779 GeneCards: ZEB1
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	31,529,814 bp[1]
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)[2]
End	5,775,467 bp[2]
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • GO:0001106 transcription corepressor activity; • GO:0001105 transcription coactivator activity; • zinc ion binding; • transcription factor binding; • chromatin binding; • metal ion binding; • GO:0001948 protein binding; • nucleic acid binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • E-box binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	• transcription factor complex; • cell nucleus; • nucleoplasm; • cytosol;
Biological process	• pattern specification process; • embryonic skeletal system morphogenesis; • regulation of smooth muscle cell differentiation; • animal organ development; • cell differentiation; • semicircular canal morphogenesis; • regulation of transcription, DNA-templated; • regulation of transcription from RNA polymerase II promoter; • transcription, DNA-templated; • nervous system development; • regulation of transforming growth factor beta receptor signaling pathway; • regulation of T cell differentiation in thymus; • central nervous system development; • cartilage development; • regulation of mesenchymal cell proliferation; • embryonic camera-type eye morphogenesis; • cochlea morphogenesis; • immune response; • embryonic morphogenesis; • cellular response to amino acid stimulus; • cellular proliferation; • negative regulation of epithelial cell differentiation; • positive regulation of transcription from RNA polymerase II promoter; • negative regulation of cell proliferation; • negative regulation of transcription, DNA-templated; • positive regulation of neuron differentiation; • negative regulation of transcription from RNA polymerase II promoter; • negative regulation of endothelial cell differentiation; • cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6935
	21417
	ENSG00000148516
	ENSMUSG00000024238
	P37275
	Q64318
NM_001128128; NM_001174093; NM_001174094; NM_001174095; NM_001174096;
	NM_030751; NM_001323638; NM_001323641; NM_001323642; NM_001323643; NM_001323644; NM_001323645; NM_001323646; NM_001323647; NM_001323648; NM_001323649; NM_001323650; NM_001323651; NM_001323652; NM_001323653; NM_001323654; NM_001323655; NM_001323656; NM_001323657; NM_001323658; NM_001323659; NM_001323660; NM_001323661; NM_001323662; NM_001323663; NM_001323664; NM_001323665; NM_001323666; NM_001323671; NM_001323672; NM_001323673; NM_001323674; NM_001323675; NM_001323676; NM_001323677; NM_001323678
	NM_011546; NM_001360981; NM_001360982
NP_001121600; NP_001167564; NP_001167565; NP_001167566; NP_001167567;
	NP_001310567; NP_001310570; NP_001310571; NP_001310572; NP_001310573; NP_001310574; NP_001310575; NP_001310576; NP_001310577; NP_001310578; NP_001310579; NP_001310580; NP_001310581; NP_001310582; NP_001310583; NP_001310584; NP_001310585; NP_001310586; NP_001310587; NP_001310588; NP_001310589; NP_001310590; NP_001310591; NP_001310592; NP_001310593; NP_001310594; NP_001310595; NP_001310600; NP_001310601; NP_001310602; NP_001310603; NP_001310604; NP_001310605; NP_001310606; NP_001310607; NP_110378
	NP_035676; NP_001347910; NP_001347911
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.[5][6][7]

ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.[7][8] ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has 7 zinc fingers and 1 homeodomain.[9] The structure of the homeodomain is shown on the right.

Clinical significance

Mutations of the gene are linked to posterior polymorphous corneal dystrophy 3. ZEB1 downregulates E-cadherin and induces epithelial to mesenchymal transition in breast and other carcinomas.[10] A recent study suggested its contributing role in lung cancer invasiveness and metastasis development.[11]. ZEB1 contributes to bone-specific metastasis of breast carcinomas by inactivating BMP signaling through the induction of the expression of BMP-inhibitors.

References

GRCh38: Ensembl release 89: ENSG00000148516 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024238 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Williams TM, Montoya G, Wu Y, Eddy RL, Byers MG, Shows TB (September 1992). "The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2". Genomics. 14 (1): 194–6. doi:10.1016/S0888-7543(05)80307-6. PMID 1427828.
Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science. 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704.
"Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1".
Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science. 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704.
Bürglin TR, Affolter M (July 2016). "Homeodomain proteins: an update". Chromosoma. 125 (3): 497–521. doi:10.1007/s00412-015-0543-8. PMC 4901127. PMID 26464018.
Eger A, Aigner K, Sonderegger S, Dampier B, Oehler S, Schreiber M, Berx G, Cano A, Beug H, Foisner R. (March 2005). "DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells". Oncogene. 31;24 (14): 2375-85. doi:10.1038/sj.onc.1208429. PMID 15674322.CS1 maint: multiple names: authors list (link)
Liu W, Huang YJ, Liu C, Yang YY, Liu H, Cui JG, Cheng Y, Gao F, Cai JM, Li BL (April 2014). "Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1". Laboratory Investigation; A Journal of Technical Methods and Pathology. 94 (4): 362–70. doi:10.1038/labinvest.2013.153. PMID 24468793.

External links

FactorBook ZEB1

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148516 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024238 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1427828-5] Williams TM, Montoya G, Wu Y, Eddy RL, Byers MG, Shows TB (September 1992). "The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2". Genomics. 14 (1): 194–6. doi:10.1016/S0888-7543(05)80307-6. PMID 1427828.

[pmid1840704-6] Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science. 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704.

[entrez-7] "Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1".

[autogenerated1-8] Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science. 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704.

[pmid26464018-9] Bürglin TR, Affolter M (July 2016). "Homeodomain proteins: an update". Chromosoma. 125 (3): 497–521. doi:10.1007/s00412-015-0543-8. PMC 4901127. PMID 26464018.

[10] Eger A, Aigner K, Sonderegger S, Dampier B, Oehler S, Schreiber M, Berx G, Cano A, Beug H, Foisner R. (March 2005). "DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells". Oncogene. 31;24 (14): 2375-85. doi:10.1038/sj.onc.1208429. PMID 15674322.CS1 maint: multiple names: authors list (link)

[pmid24468793-11] Liu W, Huang YJ, Liu C, Yang YY, Liu H, Cui JG, Cheng Y, Gao F, Cai JM, Li BL (April 2014). "Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1". Laboratory Investigation; A Journal of Technical Methods and Pathology. 94 (4): 362–70. doi:10.1038/labinvest.2013.153. PMID 24468793.

ZEB1

Clinical significance

References

Further reading

External links