SIX2

SIX2
Identifiers
Aliases	SIX2, SIX homeobox 2
External IDs	OMIM: 604994 MGI: 102778 HomoloGene: 56518 GeneCards: SIX2
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	45,009,452 bp[1]
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)[2]
End	85,688,274 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • sequence-specific DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • transcription factor binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0032403 macromolecular complex binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • transcription regulatory region sequence-specific DNA binding;
Cellular component	• cell nucleus; • transcription factor complex;
Biological process	• embryonic skeletal system morphogenesis; • regulation of chondrocyte differentiation; • regulation of transcription, DNA-templated; • positive regulation of chondrocyte proliferation; • chondrocyte differentiation; • protein import into nucleus; • kidney development; • negative regulation of cell differentiation; • anatomical structure morphogenesis; • mesenchymal stem cell maintenance involved in nephron morphogenesis; • mesenchymal to epithelial transition involved in metanephros morphogenesis; • mesenchymal cell differentiation involved in kidney development; • mesenchymal stem cell proliferation; • transcription from RNA polymerase II promoter; • regulation of branching involved in ureteric bud morphogenesis; • multicellular organism development; • nephron morphogenesis; • nephron development; • middle ear morphogenesis; • embryonic digestive tract morphogenesis; • embryonic cranial skeleton morphogenesis; • regulation of ossification; • cellular proliferation; • mesodermal cell fate specification; • anterior/posterior axis specification; • metanephros development; • cell migration; • positive regulation of transcription from RNA polymerase II promoter; • condensed mesenchymal cell proliferation; • negative regulation of transcription, DNA-templated; • anatomical structure development;
	Sources:Amigo / QuickGO
Orthologs
	10736
	20472
	ENSG00000170577
	ENSMUSG00000024134
	Q9NPC8; Q8TBA2
	Q62232
	NM_016932
	NM_011380
	NP_058628; NP_058628.3
	NP_035510
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein SIX2 is a protein that in humans is encoded by the SIX2 gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000170577 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024134 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: SIX2 sine oculis homeobox homolog 2 (Drosophila)".
Oliver, Guillermo (1995). "Homeobox genes and connective tissue patterning" (PDF). Development. 121: 693–705. PMID 7720577.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
López-Ríos J, Tessmar K, Loosli F, et al. (2003). "Six3 and Six6 activity is modulated by members of the groucho family". Development. 130 (1): 185–95. doi:10.1242/dev.00185. PMID 12441302.
Ikeda K, Watanabe Y, Ohto H, Kawakami K (2002). "Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein". Mol. Cell. Biol. 22 (19): 6759–66. doi:10.1128/MCB.22.19.6759-6766.2002. PMC 134036. PMID 12215533.
Buller C, Xu X, Marquis V, et al. (2002). "Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome". Hum. Mol. Genet. 10 (24): 2775–81. doi:10.1093/hmg/10.24.2775. PMID 11734542.
Boucher CA, Winchester CL, Hamilton GM, et al. (2000). "Structure, mapping and expression of the human gene encoding the homeodomain protein, SIX2". Gene. 247 (1–2): 145–51. doi:10.1016/S0378-1119(00)00105-0. PMID 10773454.
Celli J, van Beusekom E, Hennekam RC, et al. (2000). "Familial syndromic esophageal atresia maps to 2p23-p24". Am. J. Hum. Genet. 66 (2): 436–44. doi:10.1086/302779. PMC 1288096. PMID 10677303.
Kawakami K, Ohto H, Takizawa T, Saito T (1996). "Identification and expression of six family genes in mouse retina". FEBS Lett. 393 (2–3): 259–63. doi:10.1016/0014-5793(96)00899-X. PMID 8814301.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170577 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024134 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SIX2 sine oculis homeobox homolog 2 (Drosophila)".

[6] Oliver, Guillermo (1995). "Homeobox genes and connective tissue patterning" (PDF). Development. 121: 693–705. PMID 7720577.

SIX2

References

Further reading