NFIC (gene)

NFIC
Identifiers
Aliases	NFIC, CTF, CTF5, NF-I, NFI, nuclear factor I C
External IDs	OMIM: 600729 MGI: 109591 HomoloGene: 4088 GeneCards: NFIC
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	3,469,217 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	81,455,635 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • double-stranded DNA binding; • GO:0001158 core promoter proximal region sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	• intracellular; • cell nucleus; • fibrillar center;
Biological process	• odontogenesis of dentin-containing tooth; • DNA replication; • negative regulation of transcription, DNA-templated; • regulation of transcription, DNA-templated; • transcription from RNA polymerase II promoter; • transcription, DNA-templated; • positive regulation of transcription from RNA polymerase II promoter; • negative regulation of transcription from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	4782
	18029
	ENSG00000141905
	ENSMUSG00000055053
	P08651
	P70255
	NM_001245002; NM_001245004; NM_001245005; NM_005597; NM_205843
	NM_008688; NM_026756
	NP_001231931; NP_001231933; NP_001231934; NP_005588; NP_995315
	NP_032714; NP_081032
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear factor 1 C-type is a protein that in humans is encoded by the NFIC gene.[5][6][7]

References

GRCh38: Ensembl release 89: ENSG00000141905 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000055053 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Santoro C, Mermod N, Andrews PC, Tjian R (Aug 1988). "A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs". Nature. 334 (6179): 218–24. doi:10.1038/334218a0. PMID 3398920.
Qian F, Kruse U, Lichter P, Sippel AE (Dec 1995). "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Genomics. 28 (1): 66–73. doi:10.1006/geno.1995.1107. PMID 7590749.
"Entrez Gene: NFIC nuclear factor I/C (CCAAT-binding transcription factor)".

Blau J, Xiao H, McCracken S, et al. (1996). "Three functional classes of transcriptional activation domain". Mol. Cell. Biol. 16 (5): 2044–55. doi:10.1128/MCB.16.5.2044. PMC 231191. PMID 8628270.
Wenzelides S, Altmann H, Wendler W, Winnacker EL (1996). "CTF5--a new transcriptional activator of the NFI/CTF family". Nucleic Acids Res. 24 (12): 2416–21. doi:10.1093/nar/24.12.2416. PMC 145930. PMID 8710515.
Liu Y, Bernard HU, Apt D (1997). "NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing". J. Biol. Chem. 272 (16): 10739–45. doi:10.1074/jbc.272.16.10739. PMID 9099724.
Nogues G, Kadener S, Cramer P, et al. (2003). "Transcriptional activators differ in their abilities to control alternative splicing". J. Biol. Chem. 277 (45): 43110–4. doi:10.1074/jbc.M208418200. PMID 12221105.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Norquay LD, Yang X, Sheppard P, et al. (2003). "RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin". Mol. Endocrinol. 17 (6): 1027–38. doi:10.1210/me.2003-0025. PMID 12624117.
Wickenheisser JK, Nelson-DeGrave VL, Quinn PG, McAllister JM (2004). "Increased cytochrome P450 17alpha-hydroxylase promoter function in theca cells isolated from patients with polycystic ovary syndrome involves nuclear factor-1". Mol. Endocrinol. 18 (3): 588–605. doi:10.1210/me.2003-0090. PMID 14684846.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhao LH, Ba XQ, Wang XG, et al. (2005). "BAF complex is closely related to and interacts with NF1/CTF and RNA polymerase II in gene transcriptional activation". Acta Biochim. Biophys. Sin. (Shanghai). 37 (7): 440–6. doi:10.1111/j.1745-7270.2005.00061.x. PMID 15999204.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Nilsson J, Bjursell G, Kannius-Janson M (2006). "Nuclear Jak2 and transcription factor NF1-C2: a novel mechanism of prolactin signaling in mammary epithelial cells". Mol. Cell. Biol. 26 (15): 5663–74. doi:10.1128/MCB.02095-05. PMC 1592781. PMID 16847321.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Hebbar PB, Archer TK (2007). "Chromatin-dependent cooperativity between site-specific transcription factors in vivo". J. Biol. Chem. 282 (11): 8284–91. doi:10.1074/jbc.M610554200. PMC 2528297. PMID 17186943.

External links

NFIC+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141905 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055053 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3398920-5] Santoro C, Mermod N, Andrews PC, Tjian R (Aug 1988). "A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs". Nature. 334 (6179): 218–24. doi:10.1038/334218a0. PMID 3398920.

[pmid7590749-6] Qian F, Kruse U, Lichter P, Sippel AE (Dec 1995). "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Genomics. 28 (1): 66–73. doi:10.1006/geno.1995.1107. PMID 7590749.

[entrez-7] "Entrez Gene: NFIC nuclear factor I/C (CCAAT-binding transcription factor)".

NFIC (gene)

References

Further reading

External links