E2F2

Transcription factor E2F2 is a protein that in humans is encoded by the E2F2 gene.[5][6]

E2F2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesE2F2, E2F-2, E2F transcription factor 2
External IDsOMIM: 600426 MGI: 1096341 HomoloGene: 48264 GeneCards: E2F2
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p36.12Start23,506,438 bp[1]
End23,531,233 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

1870

242705

Ensembl

ENSG00000007968
ENSG00000282899

ENSMUSG00000018983

UniProt

Q14209

P56931

RefSeq (mRNA)

NM_004091

NM_177733
NM_183301
NM_001305399

RefSeq (protein)

NP_004082

NP_001292328
NP_808401

Location (UCSC)Chr 1: 23.51 – 23.53 MbChr 4: 136.17 – 136.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.[7]

Interactions

E2F2 has been shown to interact with:

See also

References

  1. ENSG00000282899 GRCh38: Ensembl release 89: ENSG00000007968, ENSG00000282899 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000018983 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ivey-Hoyle M, Conroy R, Huber HE, Goodhart PJ, Oliff A, Heimbrook DC (January 1994). "Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F". Mol Cell Biol. 13 (12): 7802–12. doi:10.1128/MCB.13.12.7802. PMC 364852. PMID 8246995.
  6. Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K (January 1994). "The retinoblastoma protein binds to a family of E2F transcription factors". Mol Cell Biol. 13 (12): 7813–25. doi:10.1128/mcb.13.12.7813. PMC 364853. PMID 8246996.
  7. "Entrez Gene: E2F2 E2F transcription factor 2".
  8. Crowley TE, Kaine EM, Yoshida M, Nandi A, Wolgemuth DJ (August 2002). "Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein". Mol. Endocrinol. 16 (8): 1727–37. doi:10.1210/me.2001-0353. PMID 12145330.
  9. Denis GV, Vaziri C, Guo N, Faller DV (August 2000). "RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F". Cell Growth Differ. 11 (8): 417–24. PMC 3968681. PMID 10965846.
  10. Schlisio S, Halperin T, Vidal M, Nevins JR (November 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". EMBO J. 21 (21): 5775–86. doi:10.1093/emboj/cdf577. PMC 131074. PMID 12411495.
  11. Lee C, Chang JH, Lee HS, Cho Y (December 2002). "Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor". Genes Dev. 16 (24): 3199–212. doi:10.1101/gad.1046102. PMC 187509. PMID 12502741.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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