NKX2-3

NKX2-3
Identifiers
Aliases	NKX2-3, CSX3, NK2.3, NKX2.3, NKX2C, NKX4-3, NK2 homeobox 3
External IDs	OMIM: 606727 MGI: 97348 HomoloGene: 17061 GeneCards: NKX2-3
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	99,536,524 bp[1]
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)[2]
End	43,615,892 bp[2]
Gene ontology
Molecular function	• sequence-specific DNA binding; • DNA binding; • molecular function; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity;
Cellular component	• cell nucleus; • cellular component;
Biological process	• leukocyte homeostasis; • CD4-positive, alpha-beta T cell differentiation; • post-embryonic digestive tract morphogenesis; • regulation of transcription, DNA-templated; • plasma cell differentiation; • spleen development; • post-embryonic development; • transcription, DNA-templated; • macrophage differentiation; • mucosal-associated lymphoid tissue development; • odontogenesis of dentin-containing tooth; • gland morphogenesis; • regulation of cell proliferation; • immune response; • B cell differentiation; • Peyer's patch development; • digestive tract development; • lymph node development; • triglyceride metabolic process; • leukocyte migration; • positive regulation of transcription from RNA polymerase II promoter; • biological process; • cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	159296
	18089
	ENSG00000119919
	ENSMUSG00000044220
	Q8TAU0
	P97334
	NM_145285
	NM_008699
	NP_660328
	NP_032725
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Nkx-2.3 is a protein that in humans is encoded by the NKX2-3 gene.[5][6][7]

NKX2C is a member of the NKX family of homeodomain-containing transcription factors, which are implicated in many aspects of cell type specification and maintenance of differentiated tissue functions.[7]

References

GRCh38: Ensembl release 89: ENSG00000119919 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000044220 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Price M, Lazzaro D, Pohl T, Mattei MG, Ruther U, Olivo JC, Duboule D, Di Lauro R (Mar 1992). "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain". Neuron. 8 (2): 241–55. doi:10.1016/0896-6273(92)90291-K. PMID 1346742.
Pabst O, Schneider A, Brand T, Arnold HH (Jul 1997). "The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development". Dev Dyn. 209 (1): 29–35. doi:10.1002/(SICI)1097-0177(199705)209:1<29::AID-AJA3>3.0.CO;2-Z. PMID 9142493.
"Entrez Gene: NKX2-3 NK2 transcription factor related, locus 3 (Drosophila)".

Harvey RP (1996). "NK-2 homeobox genes and heart development". Dev. Biol. 178 (2): 203–16. doi:10.1006/dbio.1996.0212. PMID 8812123.
Pabst O, Zweigerdt R, Arnold HH (1999). "Targeted disruption of the homeobox transcription factor Nkx2-3 in mice results in postnatal lethality and abnormal development of small intestine and spleen". Development. 126 (10): 2215–25. PMID 10207146.
Phiel CJ, Gabbeta V, Parsons LM, et al. (2001). "Differential binding of an SRF/NK-2/MEF2 transcription factor complex in normal versus neoplastic smooth muscle tissues". J. Biol. Chem. 276 (37): 34637–50. doi:10.1074/jbc.M105826200. PMID 11457859.
Biben C, Wang CC, Harvey RP (2003). "NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is required for salivary gland and tooth morphogenesis". Int. J. Dev. Biol. 46 (4): 415–22. PMID 12141427.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119919 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044220 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1346742-5] Price M, Lazzaro D, Pohl T, Mattei MG, Ruther U, Olivo JC, Duboule D, Di Lauro R (Mar 1992). "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain". Neuron. 8 (2): 241–55. doi:10.1016/0896-6273(92)90291-K. PMID 1346742.

[pmid9142493-6] Pabst O, Schneider A, Brand T, Arnold HH (Jul 1997). "The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development". Dev Dyn. 209 (1): 29–35. doi:10.1002/(SICI)1097-0177(199705)209:1<29::AID-AJA3>3.0.CO;2-Z. PMID 9142493.

[entrez-7] "Entrez Gene: NKX2-3 NK2 transcription factor related, locus 3 (Drosophila)".

NKX2-3

References

Further reading