HOXB3

HOXB3
Identifiers
Aliases	HOXB3, HOX2, HOX2G, Hox-2.7, homeobox B3
External IDs	OMIM: 142966 MGI: 96184 HomoloGene: 1617 GeneCards: HOXB3
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	48,604,912 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	96,347,930 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • DNA binding; • sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	• cell nucleus;
Biological process	• embryonic skeletal system morphogenesis; • multicellular organism development; • glossopharyngeal nerve morphogenesis; • definitive hemopoiesis; • thyroid gland development; • cartilage development; • face development; • regulation of transcription, DNA-templated; • negative regulation of transcription from RNA polymerase II promoter; • regulation of neurogenesis; • rhombomere development; • angiogenesis; • hematopoietic progenitor cell differentiation; • transcription, DNA-templated; • anterior/posterior pattern specification; • positive regulation of transcription from RNA polymerase II promoter; • transcription from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	3213
	15410
	ENSG00000120093
	ENSMUSG00000048763
	P14651
	P09026
	NM_002146; NM_001330322; NM_001330323
	NM_001079869; NM_010458
	NP_001317251; NP_001317252; NP_002137
	NP_001073338; NP_034588
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene.[5][6][7]

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML).[7]

References

GRCh38: Ensembl release 89: ENSG00000120093 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000048763 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
"Entrez Gene: HOXB3 homeobox B3".

Giampaolo A, Acampora D, Zappavigna V, et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation. 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.
Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
Guazzi S, Lonigro R, Pintonello L, et al. (1994). "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins". EMBO J. 13 (14): 3339–47. doi:10.1002/j.1460-2075.1994.tb06636.x. PMC 395231. PMID 7913891.
Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. doi:10.1159/000134320. PMID 8646877.
Bingle CD, Gowan S (1996). "Oct-1 interacts with conserved motifs in the human thyroid transcription factor 1 gene minimal promoter". Biochem. J. 319 ( Pt 3) (Pt 3): 669–74. doi:10.1042/bj3190669. PMC 1217841. PMID 8920965.
Sauvageau G, Thorsteinsdottir U, Hough MR, et al. (1997). "Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation". Immunity. 6 (1): 13–22. doi:10.1016/S1074-7613(00)80238-1. PMID 9052833.
Guazzi S, Pintonello ML, Viganò A, Boncinelli E (1998). "Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells". J. Biol. Chem. 273 (18): 11092–9. doi:10.1074/jbc.273.18.11092. PMID 9556594.
Viganò MA, Di Rocco G, Zappavigna V, Mavilio F (1998). "Definition of the Transcriptional Activation Domains of Three Human HOX Proteins Depends on the DNA-Binding Context". Mol. Cell. Biol. 18 (11): 6201–12. doi:10.1128/MCB.18.11.6201. PMC 109207. PMID 9774637.
Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
Nakamura N, Yoshimi T, Miura T (2002). "Increased gene expression of lung marker proteins in the homeobox B3-overexpressed fetal lung cell line M3E3/C3". Cell Growth Differ. 13 (4): 195–203. PMID 11971819.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Pineault N, Abramovich C, Ohta H, Humphries RK (2004). "Differential and Common Leukemogenic Potentials of Multiple NUP98-Hox Fusion Proteins Alone or with Meis1". Mol. Cell. Biol. 24 (5): 1907–17. doi:10.1128/MCB.24.5.1907-1917.2004. PMC 350554. PMID 14966272.
Roche J, Zeng C, Barón A, et al. (2004). "Hox expression in AML identifies a distinct subset of patients with intermediate cytogenetics". Leukemia. 18 (6): 1059–63. doi:10.1038/sj.leu.2403366. PMID 15085154.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Speleman F, Cauwelier B, Dastugue N, et al. (2005). "A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias". Leukemia. 19 (3): 358–66. doi:10.1038/sj.leu.2403657. PMID 15674412.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

HOXB3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120093 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048763 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1973146-5] McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.

[pmid1358459-6] Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.

[entrez-7] "Entrez Gene: HOXB3 homeobox B3".

HOXB3

See also

References

Further reading

External links