MEIS1

Homeobox protein Meis1 is a protein that in humans is encoded by the MEIS1 gene.[3][4]

MEIS1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesMEIS1, Meis homeobox 1
External IDsOMIM: 601739 HomoloGene: 135741 GeneCards: MEIS1
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p14Start66,433,452 bp[1]
End66,573,869 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4211

n/a

Ensembl

ENSG00000143995

n/a

UniProt

O00470

n/a

RefSeq (mRNA)

NM_002398

n/a

RefSeq (protein)

NP_002389

n/a

Location (UCSC)Chr 2: 66.43 – 66.57 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.[4]

Interactions

MEIS1 has been shown to interact with PBX1[5][6][7] and HOXA9.[5][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000143995 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Moskow JJ, Bullrich F, Huebner K, Daar IO, Buchberg AM (Oct 1995). "Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice". Molecular and Cellular Biology. 15 (10): 5434–43. doi:10.1128/mcb.15.10.5434. PMC 230793. PMID 7565694.
  4. "Entrez Gene: MEIS1 Meis homeobox 1".
  5. Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology. 19 (4): 3051–61. doi:10.1128/mcb.19.4.3051. PMC 84099. PMID 10082572.
  6. Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS (Nov 1999). "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Molecular and Cellular Biology. 19 (11): 7577–88. doi:10.1128/mcb.19.11.7577. PMC 84774. PMID 10523646.
  7. Jacobs Y, Schnabel CA, Cleary ML (Jul 1999). "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity". Molecular and Cellular Biology. 19 (7): 5134–42. doi:10.1128/mcb.19.7.5134. PMC 84356. PMID 10373562.
  8. Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C (Nov 1997). "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Molecular and Cellular Biology. 17 (11): 6448–58. doi:10.1128/MCB.17.11.6448. PMC 232497. PMID 9343407.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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