RFX4

Transcription factor RFX4 is a protein that in humans is encoded by the RFX4 gene.[5][6][7]

RFX4
Identifiers
AliasesRFX4, NYD-SP10, regulatory factor X4
External IDsOMIM: 603958 MGI: 1918387 HomoloGene: 31119 GeneCards: RFX4
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q23.3Start106,582,907 bp[1]
End106,762,803 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

5992

71137

Ensembl

ENSG00000111783

ENSMUSG00000020037

UniProt

Q33E94

Q7TNK1

RefSeq (mRNA)

NM_213594
NM_001206691
NM_002920
NM_032491

NM_001024918
NM_027689

RefSeq (protein)

NP_001193620
NP_115880
NP_998759

NP_001020089
NP_081965

Location (UCSC)Chr 12: 106.58 – 106.76 MbChr 10: 84.76 – 84.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. This protein may be a transcriptional repressor rather than a transcriptional activator. Three transcript variants encoding different isoforms have been described for this gene.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000111783 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020037 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Emery P, Durand B, Mach B, Reith W (May 1996). "RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom". Nucleic Acids Res. 24 (5): 803–7. doi:10.1093/nar/24.5.803. PMC 145730. PMID 8600444.
  6. Morotomi-Yano K, Yano K, Saito H, Sun Z, Iwama A, Miki Y (Jan 2002). "Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members". J Biol Chem. 277 (1): 836–42. doi:10.1074/jbc.M108638200. PMID 11682486.
  7. "Entrez Gene: RFX4 regulatory factor X, 4 (influences HLA class II expression)".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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