ZBTB7B

Zinc finger and BTB domain-containing protein 7B is a protein that in humans is encoded by the ZBTB7B gene.[5][6][7] ZFP67 is an early growth response gene that encodes a zinc finger-containing transcription factor that binds to the promoter regions of type I collagen genes (e.g. COL1A1; MIM 120150) and has a role in development.[supplied by OMIM][7]

ZBTB7B
Identifiers
Aliases	ZBTB7B, THPOK, ZBTB15, ZFP-67, ZFP67, ZNF857B, c-KROX, hcKROX, CKROX, zinc finger and BTB domain containing 7B
External IDs	OMIM: 607646 MGI: 102755 HomoloGene: 7605 GeneCards: ZBTB7B
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 155,002,630 bp[1] End 155,018,522 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 39.09 cM Start 89,377,644 bp[2] End 89,394,776 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • GO:0001948 protein binding • metal ion binding • nucleic acid binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001158 core promoter proximal region sequence-specific DNA binding • protein homodimerization activity • histone deacetylase binding Cellular component • cell nucleus • nucleoplasm Biological process • multicellular organism development • ectoderm development • cell differentiation • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • transcription, DNA-templated • regulation of CD4-positive, alpha-beta T cell differentiation • regulation of CD8-positive, alpha-beta T cell differentiation • positive regulation of transcription from RNA polymerase II promoter • regulation of gene expression • negative regulation of T-helper 17 cell differentiation • lactation • positive regulation of gene expression • response to insulin • positive regulation of CD4-positive, alpha-beta T cell differentiation • negative regulation of CD8-positive, alpha-beta T cell differentiation • positive regulation of insulin receptor signaling pathway • positive regulation of brown fat cell differentiation • adaptive thermogenesis • positive regulation of SREBP signaling pathway • negative regulation of transcription from RNA polymerase II promoter • NK T cell differentiation • negative regulation of gene expression • positive regulation of histone deacetylation • negative regulation of NK T cell proliferation • regulation of transcription involved in cell fate commitment • interleukin-17 secretion • positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51043	22724
Ensembl	ENSG00000160685	ENSMUSG00000028042
UniProt	O15156	Q64321
RefSeq (mRNA)	NM_001252406 NM_001256455 NM_001377451 NM_001377452 NM_001377453 NM_001377454 NM_001377455	NM_009565 NM_001355206 NM_001355211 NM_001355212
RefSeq (protein)	NP_001239335 NP_001243384 NP_001364380 NP_001364381 NP_001364382 NP_001364383 NP_001364384	NP_033591 NP_001342135 NP_001342140 NP_001342141
Location (UCSC)	Chr 1: 155 – 155.02 Mb	Chr 3: 89.38 – 89.39 Mb
PubMed search	[3]	[4]
Wikidata
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