ARID3B

AT-rich interactive domain-containing protein 3B is a protein that in humans is encoded by the ARID3B gene.[5]

ARID3B
Identifiers
AliasesARID3B, BDP, DRIL2, AT-rich interaction domain 3B
External IDsOMIM: 612457 MGI: 1930768 HomoloGene: 4721 GeneCards: ARID3B
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q24.1Start74,541,177 bp[1]
End74,598,131 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10620

56380

Ensembl

ENSG00000179361

ENSMUSG00000004661

UniProt

Q8IVW6

Q9Z1N7

RefSeq (mRNA)

NM_001307939
NM_006465

NM_019689
NM_001379353

RefSeq (protein)

NP_001294868
NP_006456

NP_062663

Location (UCSC)Chr 15: 74.54 – 74.6 MbChr 9: 57.79 – 57.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification.[5]

References
  1. GRCh38: Ensembl release 89: ENSG00000179361 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000004661 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: ARID3B AT rich interactive domain 3B (BRIGHT-like)".

Further reading
  • Kortschak RD, Tucker PW, Saint R (Jun 2000). "ARID proteins come in from the desert". Trends in Biochemical Sciences. 25 (6): 294–9. doi:10.1016/S0968-0004(00)01597-8. PMID 10838570.
  • Numata S, Claudio PP, Dean C, Giordano A, Croce CM (Aug 1999). "Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product". Cancer Research. 59 (15): 3741–7. PMID 10446990.
  • Liao TT, Hsu WH, Ho CH, Hwang WL, Lan HY, Lo T, Chang CC, Tai SK, Yang MH (2016). "let-7 Modulates Chromatin Configuration and Target Gene Repression through Regulation of the ARID3B Complex". Cell Reports. 14 (3): 520–33. doi:10.1016/j.celrep.2015.12.064. PMID 26776511.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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