KLF12

KLF12
Identifiers
Aliases	KLF12, AP-2rep, AP2REP, HSPC122, Kruppel-like factor 12, Kruppel like factor 12
External IDs	OMIM: 607531 MGI: 1333796 HomoloGene: 21417 GeneCards: KLF12
Gene location (Human)
Chr.	Chromosome 13 (human)[1]
End	73,995,056 bp[1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[2]
End	100,284,679 bp[2]
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • GO:0001948 protein binding; • GO:0001106 transcription corepressor activity; • metal ion binding; • nucleic acid binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • RNA polymerase II regulatory region sequence-specific DNA binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific;
Cellular component	• cell nucleus; • nucleoplasm; • cytosol;
Biological process	• regulation of transcription from RNA polymerase II promoter; • regulation of transcription, DNA-templated; • transcription, DNA-templated; • negative regulation of transcription from RNA polymerase II promoter; • positive regulation of transcription from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	11278
	16597
	ENSG00000118922
	ENSMUSG00000072294
	Q9Y4X4
	O35738
	NM_007249; NM_016285
	NM_010636
	NP_009180
	NP_034766
	Wikidata
View/Edit Human	View/Edit Mouse

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.[5][6]

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.[6]

References

GRCh38: Ensembl release 89: ENSG00000118922 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000072294 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Roth C, Schuierer M, Gunther K, Buettner R (Jul 2000). "Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12)". Genomics. 63 (3): 384–90. doi:10.1006/geno.1999.6084. PMID 10704285.
"Entrez Gene: KLF12 Kruppel-like factor 12".

Imhof A, Schuierer M, Werner O, et al. (1999). "Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor". Mol. Cell. Biol. 19 (1): 194–204. doi:10.1128/MCB.19.1.194. PMC 83878. PMID 9858544.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Schuierer M, Hilger-Eversheim K, Dobner T, et al. (2001). "Induction of AP-2alpha expression by adenoviral infection involves inactivation of the AP-2rep transcriptional corepressor CtBP1". J. Biol. Chem. 276 (30): 27944–9. doi:10.1074/jbc.M100070200. PMID 11373277.
Zhu CH, Huang Y, Broman MT, Domann FE (2001). "Expression of AP-2 alpha in SV40 immortalized human lung fibroblasts is associated with a distinct pattern of cytosine methylation in the AP-2 alpha promoter". Biochim. Biophys. Acta. 1519 (1–2): 85–91. doi:10.1016/s0167-4781(01)00227-5. PMID 11406275.
Chen C, Brabham WW, Stultz BG, et al. (2001). "Defining a common region of deletion at 13q21 in human cancers". Genes Chromosomes Cancer. 31 (4): 333–44. doi:10.1002/gcc.1152. PMID 11433524.
Rozenblum E, Vahteristo P, Sandberg T, et al. (2002). "A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes". Hum. Genet. 110 (2): 111–21. doi:10.1007/s00439-001-0646-6. PMID 11935316.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Suda S, Rai T, Sohara E, et al. (2006). "Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter". Biochem. Biophys. Res. Commun. 344 (1): 246–52. doi:10.1016/j.bbrc.2006.03.138. PMID 16615998.

External links

KLF12+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118922 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000072294 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10704285-5] Roth C, Schuierer M, Gunther K, Buettner R (Jul 2000). "Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12)". Genomics. 63 (3): 384–90. doi:10.1006/geno.1999.6084. PMID 10704285.

[entrez-6] "Entrez Gene: KLF12 Kruppel-like factor 12".

KLF12

See also

References

Further reading

External links