TAL1

TAL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YPA, 2YPB
Identifiers
Aliases	TAL1, SCL, TCL5, bHLHa17, tal-1, T-cell acute lymphocytic leukemia 1, TAL bHLH transcription factor 1, erythroid differentiation factor
External IDs	OMIM: 187040 MGI: 98480 HomoloGene: 2400 GeneCards: TAL1
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	47,232,220 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	115,071,755 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • DNA binding; • RNA polymerase II regulatory region sequence-specific DNA binding; • protein dimerization activity; • RNA polymerase II transcription factor binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • histone deacetylase binding; • chromatin binding; • transcription regulatory region sequence-specific DNA binding; • E-box binding; • GO:0001948 protein binding; • protein heterodimerization activity; • enzyme binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	• histone deacetylase complex; • transcription factor complex; • nuclear chromatin; • Lsd1/2 complex; • cell nucleus; • nucleoplasm; • macromolecular complex;
Biological process	• megakaryocyte development; • megakaryocyte differentiation; • myeloid cell differentiation; • cell fate commitment; • cell differentiation; • regulation of transcription, DNA-templated; • regulation of mast cell differentiation; • spinal cord association neuron differentiation; • positive regulation of protein complex assembly; • locomotory behavior; • positive regulation of erythrocyte differentiation; • regulation of transcription from RNA polymerase II promoter; • regulation of stem cell population maintenance; • platelet formation; • positive regulation of mitotic cell cycle; • negative regulation of transcription from RNA polymerase II promoter; • transcription, DNA-templated; • generation of neurons; • basophil differentiation; • positive regulation of transcription, DNA-templated; • multicellular organism development; • regulation of cell proliferation; • hematopoietic stem cell differentiation; • astrocyte fate commitment; • angiogenesis; • neuron differentiation; • embryonic hemopoiesis; • positive regulation of chromatin assembly or disassembly; • erythrocyte differentiation; • definitive hemopoiesis; • regulation of myeloid cell differentiation; • positive regulation of cell division; • hemangioblast cell differentiation; • positive regulation of transcription from RNA polymerase II promoter; • erythrocyte maturation; • regulation of hematopoietic stem cell differentiation; • haematopoiesis; • transcription from RNA polymerase II promoter; • negative regulation of erythrocyte differentiation; • positive regulation of protein tyrosine kinase activity; • positive regulation of receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	6886
	21349
	ENSG00000162367
	ENSMUSG00000028717
	P17542
	P22091
NM_001287347; NM_001290403; NM_001290404; NM_001290405; NM_001290406;
	NM_003189
	NM_011527; NM_001287388
NP_001274276; NP_001277332; NP_001277333; NP_001277334; NP_001277335;
	NP_003180
	NP_001274317; NP_035657
	Wikidata
View/Edit Human	View/Edit Mouse

T-cell acute lymphocytic leukemia protein 1 (i.e. TAL1 but also termed stem cell leukemia/T-cell acute leukemia 1 [i.e. SCL/TAL1]) is a protein that in humans is encoded by the TAL1 gene.[5][6]

The protein encoded by TAL1 is a basic helix-loop-helix transcription factor.

Interactions

TAL1 has been shown to interact with:

References

GRCh38: Ensembl release 89: ENSG00000162367 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028717 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM (August 1989). "Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma". Proc Natl Acad Sci U S A. 86 (13): 5039–43. doi:10.1073/pnas.86.13.5039. PMC 297552. PMID 2740341.
"Entrez Gene: TAL1 T-cell acute lymphocytic leukemia 1".
Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T (January 2006). "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". EMBO J. 25 (2): 357–66. doi:10.1038/sj.emboj.7600934. PMC 1383517. PMID 16407974.
Huang S, Qiu Y, Stein RW, Brandt SJ (September 1999). "p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein". Oncogene. 18 (35): 4958–67. doi:10.1038/sj.onc.1202889. PMID 10490830.
Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH (October 1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. doi:10.1073/pnas.92.21.9585. PMC 40846. PMID 7568177.
Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH (August 1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. doi:10.1073/pnas.91.18.8617. PMC 44657. PMID 8078932.
Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (October 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. PMC 395422. PMID 7957052.
Huang S, Brandt SJ (March 2000). "mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor". Mol. Cell. Biol. 20 (6): 2248–59. doi:10.1128/mcb.20.6.2248-2259.2000. PMC 110841. PMID 10688671.
Lécuyer E, Herblot S, Saint-Denis M, Martin R, Begley CG, Porcher C, Orkin SH, Hoang T (October 2002). "The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1". Blood. 100 (7): 2430–40. doi:10.1182/blood-2002-02-0568. PMID 12239153.
Hsu HL, Wadman I, Baer R (April 1994). "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3181–5. doi:10.1073/pnas.91.8.3181. PMC 43539. PMID 8159721.

External links

TAL1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
FactorBook TAL1

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162367 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028717 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2740341-5] Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM (August 1989). "Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma". Proc Natl Acad Sci U S A. 86 (13): 5039–43. doi:10.1073/pnas.86.13.5039. PMC 297552. PMID 2740341.

[entrez-6] "Entrez Gene: TAL1 T-cell acute lymphocytic leukemia 1".

[pmid16407974-7] Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T (January 2006). "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". EMBO J. 25 (2): 357–66. doi:10.1038/sj.emboj.7600934. PMC 1383517. PMID 16407974.

[pmid10490830-8] Huang S, Qiu Y, Stein RW, Brandt SJ (September 1999). "p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein". Oncogene. 18 (35): 4958–67. doi:10.1038/sj.onc.1202889. PMID 10490830.

[pmid7568177-9] Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH (October 1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. doi:10.1073/pnas.92.21.9585. PMC 40846. PMID 7568177.

[pmid8078932-10] Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH (August 1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. doi:10.1073/pnas.91.18.8617. PMC 44657. PMID 8078932.

[pmid7957052-11] Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (October 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. PMC 395422. PMID 7957052.

[pmid10688671-12] Huang S, Brandt SJ (March 2000). "mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor". Mol. Cell. Biol. 20 (6): 2248–59. doi:10.1128/mcb.20.6.2248-2259.2000. PMC 110841. PMID 10688671.

[pmid12239153-13] Lécuyer E, Herblot S, Saint-Denis M, Martin R, Begley CG, Porcher C, Orkin SH, Hoang T (October 2002). "The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1". Blood. 100 (7): 2430–40. doi:10.1182/blood-2002-02-0568. PMID 12239153.

[pmid8159721-14] Hsu HL, Wadman I, Baer R (April 1994). "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3181–5. doi:10.1073/pnas.91.8.3181. PMC 43539. PMID 8159721.

TAL1

Interactions

References

Further reading

External links