NFATC4

Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene.[5][6]

NFATC4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNFATC4, NF-AT3, NF-ATC4, NFAT3, nuclear factor of activated T-cells 4, nuclear factor of activated T cells 4
External IDsOMIM: 602699 MGI: 1920431 HomoloGene: 3349 GeneCards: NFATC4
Gene location (Human)
Chr.Chromosome 14 (human)[1]
Band14q12Start24,365,673 bp[1]
End24,379,604 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4776

73181

Ensembl

ENSG00000100968
ENSG00000285485

ENSMUSG00000023411

UniProt

Q14934

Q8K120

RefSeq (mRNA)

NM_001168346
NM_023699

RefSeq (protein)

NP_001161818
NP_076188

Location (UCSC)Chr 14: 24.37 – 24.38 MbChr 14: 55.82 – 55.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4.[6]

Interactions

NFATC4 has been shown to interact with CREB-binding protein.[7]

See also

References

  1. ENSG00000285485 GRCh38: Ensembl release 89: ENSG00000100968, ENSG00000285485 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000023411 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hoey T, Sun YL, Williamson K, Xu X (May 1995). "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity. 2 (5): 461–72. doi:10.1016/1074-7613(95)90027-6. PMID 7749981.
  6. "Entrez Gene: NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4".
  7. Yang T, Davis RJ, Chow CW (Oct 2001). "Requirement of two NFATc4 transactivation domains for CBP potentiation". The Journal of Biological Chemistry. 276 (43): 39569–76. doi:10.1074/jbc.M102961200. PMID 11514544.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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