SOX12

SOX12 is a protein that in humans is encoded by the SOX12 gene.[5][6] Sox12 belongs to the SoxC group of Sox family of transcription factors, together with Sox4 and Sox11. Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice. This probably comes from functional redundancy with Sox4 and Sox11.[7] Sox12 is a weaker activator than both Sox4 and Sox11 in mouse.[8]

SOX12
Identifiers
Aliases	SOX12, SOX22, SRY-box 12, SRY-box transcription factor 12
External IDs	OMIM: 601947 MGI: 98360 HomoloGene: 5057 GeneCards: SOX12
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 325,595 bp[1] End 330,224 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 G3 Start 152,393,611 bp[2] End 152,398,063 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • GO:0001105 transcription coactivator activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • transcription regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • protein-DNA complex • cell nucleus • nucleoplasm • cellular component Biological process • regulation of transcription from RNA polymerase II promoter • protein-DNA complex assembly • cell fate commitment • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter • spinal cord development • transcription, DNA-templated • cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6666	20667
Ensembl	ENSG00000177732	ENSMUSG00000051817
UniProt	O15370	Q04890
RefSeq (mRNA)	NM_006943	NM_011438
RefSeq (protein)	NP_008874	NP_035568
Location (UCSC)	Chr 20: 0.33 – 0.33 Mb	Chr 2: 152.39 – 152.4 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types.[6]