SALL2

SALL2
Identifiers
Aliases	SALL2, COLB, HSAL2, Sal-2, ZNF795, p150(Sal2), spalt-like transcription factor 2, spalt like transcription factor 2
External IDs	OMIM: 602219 MGI: 1354373 HomoloGene: 9269 GeneCards: SALL2
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	21,537,216 bp[1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[2]
End	52,328,762 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • sequence-specific DNA binding; • DNA binding; • GO:0001948 protein binding; • metal ion binding; • nucleic acid binding; • RNA polymerase II regulatory region sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0032403 macromolecular complex binding;
Cellular component	• NuRD complex; • cell nucleus;
Biological process	• eye development; • negative regulation of transcription, DNA-templated; • regulation of transcription, DNA-templated; • negative regulation of transcription from RNA polymerase II promoter; • transcription from RNA polymerase II promoter; • neural tube development; • signal transduction; • transcription, DNA-templated; • positive regulation of transcription from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	6297
	50524
	ENSG00000165821
	ENSMUSG00000049532
	Q9Y467
	Q9QX96
	NM_001291446; NM_001291447; NM_005407; NM_001364564
	NM_001244916; NM_015772
	NP_001278375; NP_001278376; NP_005398; NP_001351493
	NP_001231845; NP_056587
	Wikidata
View/Edit Human	View/Edit Mouse

Sal-like protein 2 is a protein that in humans is encoded by the SALL2 gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000165821 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000049532 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kohlhase J, Schuh R, Dowe G, Kühnlein RP, Jäckle H, Schroeder B, Schulz-Schaeffer W, Kretzschmar HA, Köhler A, Müller U, Raab-Vetter M, Burkhardt E, Engel W, Stick R (December 1996). "Isolation, characterization, and organ-specific expression of two novel human zinc finger genes related to the Drosophila gene spalt". Genomics. 38 (3): 291–8. doi:10.1006/geno.1996.0631. PMID 8975705.
"Entrez Gene: SALL2 sal-like 2 (Drosophila)".

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX 10.1.1.500.923. doi:10.1093/dnares/9.3.99. PMID 12168954.
Sweetman D, Münsterberg A (May 2006). "The vertebrate spalt genes in development and disease". Developmental Biology. 293 (2): 285–93. doi:10.1016/j.ydbio.2006.02.009. PMID 16545361.
Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (April 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
Nielsen TO, Hsu FD, O'Connell JX, Gilks CB, Sorensen PH, Linn S, West RB, Liu CL, Botstein D, Brown PO, van de Rijn M (October 2003). "Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology". The American Journal of Pathology. 163 (4): 1449–56. doi:10.1016/S0002-9440(10)63502-X. PMC 1868308. PMID 14507652.
Li D, Tian Y, Ma Y, Benjamin T (May 2004). "p150(Sal2) is a p53-independent regulator of p21(WAF1/CIP)". Molecular and Cellular Biology. 24 (9): 3885–93. doi:10.1128/MCB.24.9.3885-3893.2004. PMC 387742. PMID 15082782.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165821 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049532 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8975705-5] Kohlhase J, Schuh R, Dowe G, Kühnlein RP, Jäckle H, Schroeder B, Schulz-Schaeffer W, Kretzschmar HA, Köhler A, Müller U, Raab-Vetter M, Burkhardt E, Engel W, Stick R (December 1996). "Isolation, characterization, and organ-specific expression of two novel human zinc finger genes related to the Drosophila gene spalt". Genomics. 38 (3): 291–8. doi:10.1006/geno.1996.0631. PMID 8975705.

[entrez-6] "Entrez Gene: SALL2 sal-like 2 (Drosophila)".

SALL2

References

Further reading