TLX2

TLX2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3A03
Identifiers
Aliases	TLX2, HOX11L1, NCX, T-cell leukemia homeobox 2, T cell leukemia homeobox 2
External IDs	OMIM: 604240 MGI: 1350935 HomoloGene: 7575 GeneCards: TLX2
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	74,517,148 bp[1]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity;
Cellular component	• cytoplasm; • cell nucleus; • cellular component;
Biological process	• multicellular organism development; • enteric nervous system development; • mesoderm formation; • regulation of transcription, DNA-templated; • negative regulation of dendrite morphogenesis; • transcription, DNA-templated; • transcription from RNA polymerase II promoter; • positive regulation of transcription from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	3196
	21909
	ENSG00000115297
	n/a
	O43763
	Q61663
	NM_016170
	NM_009392
	NP_057254
	NP_033418
	Wikidata
View/Edit Human	View/Edit Mouse

T-cell leukemia homeobox protein 2 is a protein that in humans is encoded by the TLX2 gene.[4][5]

Interactions

TLX2 has been shown to interact with YWHAH.[6]

GRCh38: Ensembl release 89: ENSG00000115297 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Puliti A, Cinti R, Betsos N, Romeo G, Ceccherini I (Jun 1999). "HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1-->p12 and mouse chromosome 6C3-D1". Cytogenetics and Cell Genetics. 84 (1–2): 115–7. doi:10.1159/000015234. PMID 10343123.
"Entrez Gene: TLX2 T-cell leukemia homeobox 2".
Tang SJ, Suen TC, McInnes RR, Buchwald M (September 1998). "Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins". The Journal of Biological Chemistry. 273 (39): 25356–63. doi:10.1074/jbc.273.39.25356. PMID 9738002.

Kaifi JT, Wagner M, Schurr PG, Wachowiak R, Reichelt U, Yekebas EF, Mann O, Vashist Y, Kleinhans H, Link BC, Strate T, Kalinin V, Izbicki JR (October 2006). "Allelic loss of Hox11L1 gene locus predicts outcome of gastrointestinal stromal tumors". Oncology Reports. 16 (4): 915–9. doi:10.3892/or.16.4.915. PMID 16969514.
Borghini S, Bachetti T, Fava M, Di Duca M, Cargnin F, Fornasari D, Ravazzolo R, Ceccherini I (April 2006). "The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural-crest-derived cells". The Biochemical Journal. 395 (2): 355–61. doi:10.1042/BJ20051386. PMC 1422762. PMID 16402914.
Parisi MA, Lipman NS, Clarke CM, Taylor B, Kapur RP (November 2005). "Evaluation of Hox11L1 in the fmc/fmc rat model of chronic intestinal pseudo-obstruction". Journal of Pediatric Surgery. 40 (11): 1760–5. doi:10.1016/j.jpedsurg.2005.07.010. PMID 16291166.
Iitsuka Y, Shimizu H, Kang MM, Sasagawa K, Sekiya S, Tokuhisa T, Hatano M (August 1999). "An enhancer element for expression of the Ncx (Enx, Hox11L1) gene in neural crest-derived cells". The Journal of Biological Chemistry. 274 (34): 24401–7. doi:10.1074/jbc.274.34.24401. PMID 10446220.
Tang SJ, Suen TC, McInnes RR, Buchwald M (September 1998). "Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins". The Journal of Biological Chemistry. 273 (39): 25356–63. doi:10.1074/jbc.273.39.25356. PMID 9738002.

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