RELB

RELB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZK9, 1ZKA, 2V2T, 3DO7, 3JSS, 3JUZ, 3JV0, 3JV4, 3JV6, 4JGM, 4JHB
Identifiers
Aliases	RELB, I-REL, IREL, REL-B, RELB proto-oncogene, NF-kB subunit, IMD53
External IDs	OMIM: 604758 MGI: 103289 HomoloGene: 4747 GeneCards: RELB
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	45,038,198 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	19,629,438 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • RNA polymerase II regulatory region sequence-specific DNA binding; • GO:0001106 transcription corepressor activity; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • chromatin binding; • GO:0001948 protein binding; • protein kinase binding; • identical protein binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	• I-kappaB/NF-kappaB complex; • nucleoplasm; • microtubule organizing center; • cytoskeleton; • cell nucleus; • cytoplasm; • cytosol; • centrosome; • macromolecular complex; • transcriptional repressor complex;
Biological process	• response to cytokine; • antigen processing and presentation; • regulation of transcription, DNA-templated; • rhythmic process; • regulation of transcription from RNA polymerase II promoter; • myeloid dendritic cell differentiation; • stimulatory C-type lectin receptor signaling pathway; • negative regulation of transcription from RNA polymerase II promoter; • T-helper 1 cell differentiation; • negative regulation of interferon-beta production; • circadian regulation of gene expression; • transcription, DNA-templated; • cellular response to osmotic stress; • positive regulation of gene expression; • NIK/NF-kappaB signaling; • T-helper 1 type immune response; • inflammatory response; • negative regulation of transcription, DNA-templated; • I-kappaB kinase/NF-kappaB signaling; • positive regulation of transcription from RNA polymerase II promoter; • innate immune system; • lymphocyte differentiation;
	Sources:Amigo / QuickGO
Orthologs
	5971
	19698
	ENSG00000104856
	ENSMUSG00000002983
	Q01201
	Q04863
	NM_006509
	NM_001290457; NM_009046
	NP_006500
	NP_001277386; NP_033072
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor RelB is a protein that in humans is encoded by the RELB gene.[5]

Interactions

RELB has been shown to interact with NFKB2,[6][7] NFKB1,[6] and C22orf25.[8]

References

GRCh38: Ensembl release 89: ENSG00000104856 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000002983 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Bours V, Burd PR, Brown K, Villalobos J, Park S, Ryseck RP, Bravo R, Kelly K, Siebenlist U (Feb 1992). "A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site". Molecular and Cellular Biology. 12 (2): 685–95. PMC 364259. PMID 1531086.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Thornburg NJ, Pathmanathan R, Raab-Traub N (Dec 2003). "Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma". Cancer Research. 63 (23): 8293–301. PMID 14678988.
"Molecular Interaction Database". Archived from the original on 2006-05-06.

Taylor JP, Pomerantz R, Bagasra O, Chowdhury M, Rappaport J, Khalili K, Amini S (Sep 1992). "TAR-independent transactivation by Tat in cells derived from the CNS: a novel mechanism of HIV-1 gene regulation". The EMBO Journal. 11 (9): 3395–403. PMC 556874. PMID 1505523.
Ruben SM, Klement JF, Coleman TA, Maher M, Chen CH, Rosen CA (May 1992). "I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity". Genes & Development. 6 (5): 745–60. doi:10.1101/gad.6.5.745. PMID 1577270.
Liu J, Perkins ND, Schmid RM, Nabel GJ (Jun 1992). "Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription". Journal of Virology. 66 (6): 3883–7. PMC 241175. PMID 1583734.
Biswas DK, Salas TR, Wang F, Ahlers CM, Dezube BJ, Pardee AB (Dec 1995). "A Tat-induced auto-up-regulatory loop for superactivation of the human immunodeficiency virus type 1 promoter". Journal of Virology. 69 (12): 7437–44. PMC 189681. PMID 7494249.
Jeang KT, Chun R, Lin NH, Gatignol A, Glabe CG, Fan H (Oct 1993). "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor". Journal of Virology. 67 (10): 6224–33. PMC 238044. PMID 7690421.
Alcamí J, Laín de Lera T, Folgueira L, Pedraza MA, Jacqué JM, Bachelerie F, Noriega AR, Hay RT, Harrich D, Gaynor RB (Apr 1995). "Absolute dependence on kappa B responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes". The EMBO Journal. 14 (7): 1552–60. PMC 398242. PMID 7729429.
Majello B, De Luca P, Hagen G, Suske G, Lania L (Nov 1994). "Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1". Nucleic Acids Research. 22 (23): 4914–21. doi:10.1093/nar/22.23.4914. PMC 523756. PMID 7800480.
Taylor JP, Pomerantz RJ, Oakes JW, Khalili K, Amini S (Jan 1995). "A CNS-enriched factor that binds to NF-kappa B and is required for interaction with HIV-1 tat". Oncogene. 10 (2): 395–400. PMID 7838536.
Westendorp MO, Shatrov VA, Schulze-Osthoff K, Frank R, Kraft M, Los M, Krammer PH, Dröge W, Lehmann V (Feb 1995). "HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state". The EMBO Journal. 14 (3): 546–54. PMC 398112. PMID 7859743.
Scala G, Ruocco MR, Ambrosino C, Mallardo M, Giordano V, Baldassarre F, Dragonetti E, Quinto I, Venuta S (Mar 1994). "The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 TAT protein". The Journal of Experimental Medicine. 179 (3): 961–71. doi:10.1084/jem.179.3.961. PMC 2191426. PMID 8113688.
Bours V, Azarenko V, Dejardin E, Siebenlist U (Jun 1994). "Human RelB (I-Rel) functions as a kappa B site-dependent transactivating member of the family of Rel-related proteins". Oncogene. 9 (6): 1699–702. PMID 8183565.
Deloukas P, Dauwerse JG, van Ommen GJ, van Loon AP (Feb 1994). "The human NFKB3 gene encoding the p65 subunit of transcription factor NF-kappa B is located on chromosome 11q12". Genomics. 19 (3): 592–4. doi:10.1006/geno.1994.1115. PMID 8188306.
Westendorp MO, Li-Weber M, Frank RW, Krammer PH (Jul 1994). "Human immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells". Journal of Virology. 68 (7): 4177–85. PMC 236340. PMID 8207793.
Dobrzanski P, Ryseck RP, Bravo R (Mar 1993). "Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif". Molecular and Cellular Biology. 13 (3): 1572–82. PMC 359469. PMID 8441398.
Harhaj E, Blaney J, Millhouse S, Sun SC (Feb 1996). "Differential effects of I kappa B molecules on Tat-mediated transactivation of HIV-1 LTR". Virology. 216 (1): 284–7. doi:10.1006/viro.1996.0062. PMID 8615004.
Conant K, Ma M, Nath A, Major EO (Mar 1996). "Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes". Journal of Virology. 70 (3): 1384–9. PMC 189957. PMID 8627654.
Demarchi F, d'Adda di Fagagna F, Falaschi A, Giacca M (Jul 1996). "Activation of transcription factor NF-kappaB by the Tat protein of human immunodeficiency virus type 1". Journal of Virology. 70 (7): 4427–37. PMC 190376. PMID 8676466.
Beauparlant P, Kwon H, Clarke M, Lin R, Sonenberg N, Wainberg M, Hiscott J (Sep 1996). "Transdominant mutants of I kappa B alpha block Tat-tumor necrosis factor synergistic activation of human immunodeficiency virus type 1 gene expression and virus multiplication". Journal of Virology. 70 (9): 5777–85. PMC 190591. PMID 8709193.
Ramazzotti E, Vignoli M, Re MC, Furlini G, La Placa M (May 1996). "Enhanced nuclear factor-kappa B activation induced by tumour necrosis factor-alpha in stably tat-transfected cells is associated with the presence of cell-surface-bound Tat protein". AIDS. 10 (5): 455–61. doi:10.1097/00002030-199605000-00002. PMID 8724035.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104856 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002983 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1531086-5] Bours V, Burd PR, Brown K, Villalobos J, Park S, Ryseck RP, Bravo R, Kelly K, Siebenlist U (Feb 1992). "A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site". Molecular and Cellular Biology. 12 (2): 685–95. PMC 364259. PMID 1531086.

[pmid14743216-6] Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.

[pmid14678988-7] Thornburg NJ, Pathmanathan R, Raab-Traub N (Dec 2003). "Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma". Cancer Research. 63 (23): 8293–301. PMID 14678988.

[8] "Molecular Interaction Database". Archived from the original on 2006-05-06.

RELB

Interactions

See also

References

Further reading