IRX5
Iroquois-class homeodomain protein IRX-5, also known as Iroquois homeobox protein 5, is a protein that in humans is encoded by the IRX5 gene.[3][4]
Function
IRX5 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[3]
References
- GRCh38: Ensembl release 89: ENSG00000176842 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: iroquois homeobox 1".
- Ogura K, Matsumoto K, Kuroiwa A, Isobe T, Otoguro T, Jurecic V, Baldini A, Matsuda Y, Ogura T (2001). "Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes". Cytogenet. Cell Genet. 92 (3–4): 320–5. doi:10.1159/000056921. PMID 11435706.
Further reading
- Lewis MT, Ross S, Strickland PA, et al. (1999). "Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast". Cell Tissue Res. 296 (3): 549–54. doi:10.1007/s004410051316. PMID 10370142.
- Bruneau BG (2006). "[Irx5: a transcription factor that regulates the cardiac repolarization gradient]" (PDF). Med Sci (Paris). 22 (3): 231–2. doi:10.1051/medsci/2006223231. PMID 16527195.
- Myrthue A, Rademacher BL, Pittsenbarger J, et al. (2008). "The iroquois homeobox gene 5 is regulated by 1,25-dihydroxyvitamin D3 in human prostate cancer and regulates apoptosis and the cell cycle in LNCaP prostate cancer cells". Clin. Cancer Res. 14 (11): 3562–70. doi:10.1158/1078-0432.CCR-07-4649. PMID 18519790.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Kanno S, Kuzuoka H, Sasao S, et al. (2007). "A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses". EMBO J. 26 (8): 2094–103. doi:10.1038/sj.emboj.7601663. PMC 1852789. PMID 17396150.
External links
- IRX5 human gene location in the UCSC Genome Browser.
- IRX5 human gene details in the UCSC Genome Browser.
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