Endothelin 1

EDN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EDN, 1EDP, 1T7H, 1V6R
Identifiers
Aliases	EDN1, ARCND3, ET1, HDLCQ7, PPET1, QME, endothelin 1
External IDs	MGI: 95283 HomoloGene: 1476 GeneCards: EDN1
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[1]
End	42,307,990 bp[1]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• hormone activity; • receptor binding; • cytokine activity; • endothelin B receptor binding; • protein binding; • endothelin A receptor binding;
Cellular component	• cytoplasm; • Weibel-Palade body; • basal part of cell; • extracellular region; • rough endoplasmic reticulum lumen; • extracellular space; • transport vesicle;
Biological process	• skeletal system development; • response to amino acid; • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; • negative regulation of cellular protein metabolic process; • positive regulation of MAP kinase activity; • regulation of sensory perception of pain; • vasoconstriction; • body fluid secretion; • positive regulation of sarcomere organization; • positive regulation of cardiac muscle hypertrophy; • cell surface receptor signaling pathway; • cellular response to drug; • multicellular organism aging; • artery smooth muscle contraction; • cellular response to interferon-gamma; • positive regulation of chemokine-mediated signaling pathway; • phosphatidylinositol 3-kinase signaling; • response to leptin; • positive regulation of mitotic nuclear division; • cellular response to hypoxia; • response to muscle stretch; • cellular response to calcium ion; • cellular response to transforming growth factor beta stimulus; • regulation of blood vessel size; • positive regulation of renal sodium excretion; • blood vessel morphogenesis; • negative regulation of blood coagulation; • response to nicotine; • in utero embryonic development; • neutrophil chemotaxis; • heart development; • positive regulation of prostaglandin secretion; • vein smooth muscle contraction; • cartilage development; • rhythmic excitation; • protein kinase C-activating G-protein coupled receptor signaling pathway; • cellular response to glucocorticoid stimulus; • branching involved in blood vessel morphogenesis; • negative regulation of hormone secretion; • positive regulation of smooth muscle contraction; • negative regulation of nitric-oxide synthase biosynthetic process; • positive regulation of prostaglandin-endoperoxide synthase activity; • positive regulation of urine volume; • positive regulation of JUN kinase activity; • leukocyte activation; • positive regulation of receptor biosynthetic process; • membrane depolarization; • negative regulation of transcription from RNA polymerase II promoter; • response to ozone; • respiratory gaseous exchange; • positive regulation of heart rate; • regulation of blood pressure; • response to lipopolysaccharide; • response to prostaglandin F; • regulation of vasoconstriction; • cellular response to interleukin-1; • response to salt; • positive regulation of cell size; • middle ear morphogenesis; • nociception; • prostaglandin biosynthetic process; • dorsal/ventral pattern formation; • phospholipase D-activating G-protein coupled receptor signaling pathway; • positive regulation of odontogenesis; • regulation of pH; • positive regulation of smooth muscle cell proliferation; • protein kinase C deactivation; • histamine secretion; • maternal process involved in parturition; • intracellular signal transduction; • response to hypoxia; • neural crest cell development; • regulation of systemic arterial blood pressure by endothelin; • nitric oxide transport; • positive regulation of cell migration; • response to testosterone; • positive regulation of cytosolic calcium ion concentration; • epithelial fluid transport; • positive regulation of nitric oxide biosynthetic process; • cell-cell signaling; • cellular response to tumor necrosis factor; • response to activity; • response to dexamethasone; • superoxide anion generation; • positive regulation of endothelial cell migration; • cellular response to peptide hormone stimulus; • cellular response to fatty acid; • peptide hormone secretion; • cellular response to mineralocorticoid stimulus; • positive regulation of cell proliferation; • inositol phosphate-mediated signaling; • positive regulation of hormone secretion; • negative regulation of smooth muscle cell apoptotic process; • response to drug; • calcium-mediated signaling; • response to transforming growth factor beta; • positive regulation of transcription from RNA polymerase II promoter; • positive regulation of sequence-specific DNA binding transcription factor activity; • positive regulation of cell growth involved in cardiac muscle cell development; • positive regulation of neutrophil chemotaxis; • regulation of receptor activity; • G-protein coupled receptor signaling pathway; • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; • regulation of glucose transport; • negative regulation of gene expression; • positive regulation of NIK/NF-kappaB signaling; • positive regulation of vascular smooth muscle cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	1906
	13614
	n/a
	ENSMUSG00000021367
	P05305
	P22387
	NM_001168319; NM_001955
	NM_010104
	NP_001161791; NP_001946
	NP_034234
	Wikidata
View/Edit Human	View/Edit Mouse

Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a potent vasoconstrictor that in humans is encoded by the EDN1 gene and produced by vascular endothelial cells. The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. Endothelin 1 is one of three isoforms of human endothelin.

Preproendothelin is precursor of the peptide ET-1. Endothelial cells convert preproendothelin to proendothelin and subsequently to mature endothelin, which the cells release.^[4]

Endothelin-1 receptor antagonists (Bosentan) are used in the treatment of pulmonary hypertension. Inhibition of these receptors prevents pulmonary vasculature constriction and thus decreases pulmonary vascular resistance.

References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021367 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Boulpaep EL, Boron WF (2009). Medical physiology: a cellular and molecular approach. Saunders/Elsevier. ISBN 1-4160-3115-4.

Endothelin 1

References

Further reading