Melanin-concentrating hormone receptor 2

MCHR2
Identifiers
AliasesMCHR2, GPR145, GPRv17, MCH-2R, MCH-R2, MCH2, MCH2R, MCHR-2, SLT, melanin concentrating hormone receptor 2
External IDsHomoloGene: 50004 GeneCards: MCHR2
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q16.2Start99,919,910 bp[1]
End99,994,247 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

84539

n/a

Ensembl

ENSG00000152034

n/a

UniProt

Q969V1

n/a

RefSeq (mRNA)

NM_032503
NM_001040179

n/a

RefSeq (protein)

NP_001035269
NP_115892

n/a

Location (UCSC)Chr 6: 99.92 – 99.99 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Melanin-concentrating hormone receptor 2 (MCH2) also known as G-protein coupled receptor 145 (GPR145) is a protein that in humans is encoded by the MCHR2 gene.[3][4][5]

MCH2 is also found in dogs, ferrets, and some other primates and carnivores, but is not found in mice or rats. This has delayed research into the receptor as a therapeutic target, due to most early pharmaceutical research usually being conducted in small mammals such as mice, rats or rabbits which lack the MCH2 gene and its receptor product.

Clinical significance

Treatment of human cells expressing MCHR2 with MCH resulted in upregulation of IDH3A, PCK1 and PFKFB4 and the downregulation of INSIG2 and ACOT8.[6]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000152034 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ "Entrez Gene: MCHR2 melanin-concentrating hormone receptor 2".
  4. ↑ Mori M, Harada M, Terao Y, Sugo T, Watanabe T, Shimomura Y, Abe M, Shintani Y, Onda H, Nishimura O, Fujino M (May 2001). "Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor". Biochem. Biophys. Res. Commun. 283 (5): 1013–8. doi:10.1006/bbrc.2001.4893. PMID 11355873.
  5. ↑ Hill J, Duckworth M, Murdock P, Rennie G, Sabido-David C, Ames RS, Szekeres P, Wilson S, Bergsma DJ, Gloger IS, Levy DS, Chambers JK, Muir AI (June 2001). "Molecular cloning and functional characterization of MCH2, a novel human MCH receptor". J. Biol. Chem. 276 (23): 20125–9. doi:10.1074/jbc.M102068200. PMID 11274220.
  6. ↑ Zhang Q, Yuan CF, Wu MJ, Wang YG, Qin Q, Shi YY, Liu GL, Song FZ (June 2010). "Comparative proteomic analysis of proteins influenced by melanin-concentrating hormone and melanin-concentrating hormone receptor 2 interaction". Horm. Metab. Res. 42 (7): 521–7. doi:10.1055/s-0030-1249019. PMID 20340065.
  • "Melanin-Concentrating Hormone Receptors: MCH2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further reading

  • Sailer AW, Sano H, Zeng Z, et al. (2001). "Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7564–9. doi:10.1073/pnas.121170598. PMC 34708. PMID 11404457.
  • An S, Cutler G, Zhao JJ, et al. (2001). "Identification and characterization of a melanin-concentrating hormone receptor". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7576–81. doi:10.1073/pnas.131200698. PMC 34710. PMID 11416225.
  • Wang S, Behan J, O'Neill K, et al. (2001). "Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2". J. Biol. Chem. 276 (37): 34664–70. doi:10.1074/jbc.M102601200. PMID 11459838.
  • Bednarek MA, Feighner SD, Hreniuk DL, et al. (2001). "Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2". Biochemistry. 40 (31): 9379–86. doi:10.1021/bi010867p. PMID 11478907.
  • Bednarek MA, Tan C, Hreniuk DL, et al. (2002). "Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1". J. Biol. Chem. 277 (16): 13821–6. doi:10.1074/jbc.M200563200. PMID 11839762.
  • Audinot V, Lahaye C, Suply T, et al. (2002). "SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor". Biochem. Biophys. Res. Commun. 295 (4): 841–8. doi:10.1016/S0006-291X(02)00763-5. PMID 12127971.
  • Logan DW, Bryson-Richardson RJ, Pagán KE, et al. (2003). "The structure and evolution of the melanocortin and MCH receptors in fish and mammals". Genomics. 81 (2): 184–91. doi:10.1016/S0888-7543(02)00037-X. PMID 12620396.
  • Vitale RM, Pedone C, De Benedetti PG, Fanelli F (2004). "Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations". Proteins. 56 (3): 430–48. doi:10.1002/prot.20125. PMID 15229878.
  • Hawes BE, Green B, O'Neill K, et al. (2004). "Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2". Obes. Res. 12 (8): 1327–34. doi:10.1038/oby.2004.167. PMID 15340116.


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