Dienestrol diacetate

Dienestrol diacetate
Clinical data
Trade names	Faragynol, Gynocyrol
Drug class	Nonsteroidal estrogen; Estrogen ester
Identifiers
	IUPAC name [4-[(2Z,4E)-4-(4-acetyloxyphenyl)hexa-2,4-dien-3-yl]phenyl] acetate;
CAS Number	84-19-5;
PubChem CID	24884313;
ChemSpider	4707742;
UNII	D20D148WPQ;
ChEMBL	CHEMBL3188355;
Chemical and physical data
Formula	C22H22O4
Molar mass	350.41 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C\C=C(c1ccc(OC(C)=O)cc1)/C(=C/C)c2ccc(OC(C)=O)cc2;
	InChI InChI=1S/C22H22O4/c1-5-21(17-7-11-19(12-8-17)25-15(3)23)22(6-2)18-9-13-20(14-10-18)26-16(4)24/h5-14H,1-4H3/b21-5-,22-6+; Key:YWLLGDVBTLPARJ-LWKKFVLGSA-N;

Dienestrol diacetate (brand names Faragynol, Gynocyrol, others) is a synthetic nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol.^[1] It is an ester of dienestrol.^[1]

Oral potencies of estrogens
Estrogen	Type	EPD (mg/14 days)	EPD (mg/day)	MSD (mg/14 days)	MSD (mg/day)
Estradiol (micronized)	Bioidentical	60	4.3	14–28	1.0–2.0
Estradiol valerate	Bioidentical	60	4.3	14–28	1.0–2.0
Estriol	Bioidentical	140–150^a	10.0–10.7^a	28–84	2.0–6.0
Estriol succinate	Bioidentical	140–150^a	10.0–10.7^a	28–84	2.0–6.0
Conjugated estrogens	Natural	60	4.3	8.4–17.5	0.6–1.25
Ethinylestradiol	Synthetic	1.0–1.5	0.071–0.11	0.28	0.02
Mestranol	Synthetic	1.5–1.8	0.11–0.13	0.35	0.025
Quinestrol	Synthetic	2.0–4.0	0.14–0.29	ND	ND
Diethylstilbestrol	Synthetic	20–30	1.4–2.1	ND	ND
Diethylstilbestrol dipropionate	Synthetic	15–20	1.1–1.4	ND	ND
Dienestrol diacetate	Synthetic	40–60	2.9–4.3	ND	ND
Addendum: The ovulation-inhibiting dose (OID) of ethinylestradiol is 0.1 mg/day.^[2] Footnotes: ^a = Taken in divided doses three times per day. Abbreviations: EPD = Endometrial proliferation dose. MSD = Menopausal substitution dose. Miscellaneous: Direct link to table. Sources: ^[3]^[4]^[5]^[6]

References

1 2 J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 390. ISBN 978-1-4757-2085-3.
↑ N. Rietbrock; A.H. Staib; D. Loew (11 March 2013). Klinische Pharmakologie: Arzneitherapie. Springer-Verlag. pp. 426–. ISBN 978-3-642-57636-2.
↑ Lauritzen C (September 1990). "Clinical use of oestrogens and progestogens". Maturitas. 12 (3): 199–214. doi:10.1016/0378-5122(90)90004-P. PMID 2215269.
↑ Alfred S. Wolf; H.P.G. Schneider (12 March 2013). Östrogene in Diagnostik und Therapie. Springer-Verlag. pp. 78–. ISBN 978-3-642-75101-1.
↑ Gunther Göretzlehner; Christian Lauritzen; Thomas Römer; Winfried Rossmanith (1 January 2012). Praktische Hormontherapie in der Gynäkologie. Walter de Gruyter. pp. 44–. ISBN 978-3-11-024568-4.
↑ Karl Knörr; Fritz K. Beller; Christian Lauritzen (17 April 2013). Lehrbuch der Gynäkologie. Springer-Verlag. pp. 212–213. ISBN 978-3-662-00942-0.

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