3β-Hydroxytibolone
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| Synonyms | ORG-30126; 7α-Methyl-17α-ethynylestr-5(10)-ene-3β,17β-diol |
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| Formula | C21H30O2 |
| Molar mass | 314.469 g/mol |
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3β-Hydroxytibolone (developmental code name ORG-30126) is a synthetic steroidal estrogen which was never marketed.[1][2] Along with 3α-hydroxytibolone and δ4-tibolone, it is a major active metabolite of tibolone, and 3α-hydroxytibolone and 3β-hydroxytibolone are thought to be responsible for the estrogenic activity of tibolone.[1][2]
References
- 1 2 Kuhl, H (2009). "Pharmacology of estrogens and progestogens: influence of different routes of administration". Climacteric. 8 (sup1): 3–63. doi:10.1080/13697130500148875. ISSN 1369-7137. PMID 16112947.
- 1 2 Escande A, Servant N, Rabenoelina F, Auzou G, Kloosterboer H, Cavaillès V, Balaguer P, Maudelonde T (2009). "Regulation of activities of steroid hormone receptors by tibolone and its primary metabolites". J. Steroid Biochem. Mol. Biol. 116 (1–2): 8–14. doi:10.1016/j.jsbmb.2009.03.008. PMID 19464167.
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