LGR4

LGR4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4KT1, 4QXE, 4QXF
Identifiers
Aliases	LGR4, BNMD17, GPR48, leucine-rich repeat containing G protein-coupled receptor 4, leucine rich repeat containing G protein-coupled receptor 4
External IDs	MGI: 1891468 HomoloGene: 10226 GeneCards: LGR4
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	27,472,775 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	110,014,257 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• signal transducer activity; • protein binding; • transmembrane signaling receptor activity; • G-protein coupled receptor activity; • protein-hormone receptor activity;
Cellular component	• integral component of membrane; • membrane; • integral component of plasma membrane; • plasma membrane;
Biological process	• hair follicle development; • G-protein coupled receptor signaling pathway; • cell differentiation; • positive regulation of branching involved in ureteric bud morphogenesis; • male genitalia development; • metanephric nephron tubule morphogenesis; • rhythmic process; • metanephric glomerulus development; • immune system process; • epithelial cell proliferation; • Wnt signaling pathway; • tube morphogenesis; • positive regulation of transcription, DNA-templated; • multicellular organism development; • cell differentiation involved in metanephros development; • intestinal stem cell homeostasis; • epithelial cell proliferation involved in renal tubule morphogenesis; • circadian rhythm; • canonical Wnt signaling pathway involved in metanephric kidney development; • digestive tract development; • innate immune response; • negative regulation of transcription, DNA-templated; • signal transduction; • positive regulation of canonical Wnt signaling pathway; • bone remodeling; • circadian regulation of gene expression; • spermatogenesis; • negative regulation of cytokine secretion; • osteoblast differentiation; • bone mineralization; • negative regulation of toll-like receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	55366
	107515
	ENSG00000205213
	ENSMUSG00000050199
	Q9BXB1
	A2ARI4
	NM_018490; NM_001346432
	NM_172671
	NP_001333361; NP_060960
	NP_766259
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine-rich repeat-containing G-protein coupled receptor 4 is a protein that in humans is encoded by the LGR4 gene.^[5]^[6] LGR4 is known to have a role in the development of the male reproductive tract, eyelids, hair and bone.

Mutations in this gene have been associated to osteoporosis (doi:10.1038/nature12124).

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000205213 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050199 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Loh ED, Broussard SR, Liu Q, Copeland NG, Gilbert DJ, Jenkins NA, Kolakowski LF Jr (Aug 2000). "Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping". Cytogenet Cell Genet. 89 (1–2): 2–5. doi:10.1159/000015576. PMID 10894923.
↑ "Entrez Gene: LGR4 leucine-rich repeat-containing G protein-coupled receptor 4".

Hsu SY, Liang SG, Hsueh AJ (1999). "Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region". Mol. Endocrinol. 12 (12): 1830–45. doi:10.1210/me.12.12.1830. PMID 9849958.
Loh ED, Broussard SR, Kolakowski LF (2001). "Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor". Biochem. Biophys. Res. Commun. 282 (3): 757–64. doi:10.1006/bbrc.2001.4625. PMID 11401528.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000205213 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050199 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid10894923-5] Loh ED, Broussard SR, Liu Q, Copeland NG, Gilbert DJ, Jenkins NA, Kolakowski LF Jr (Aug 2000). "Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping". Cytogenet Cell Genet. 89 (1–2): 2–5. doi:10.1159/000015576. PMID 10894923.

[entrez-6] "Entrez Gene: LGR4 leucine-rich repeat-containing G protein-coupled receptor 4".

LGR4

References

Further reading