Parathyroid hormone receptor
There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors bind parathyroid hormone and are members of the GPCR family of transmembrane proteins.[1]
- parathyroid hormone 1 receptor (PTH1R) is the classical PTH receptor, is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C.[2][3]
- parathyroid hormone 2 receptor (PTH2R) is expressed primarily in the central nervous system, pancreas, testis, and placenta.[4]
| parathyroid hormone 1 receptor | |
|---|---|
| Identifiers | |
| Symbol | PTH1R |
| Alt. symbols | PTHR, PFE |
| NCBI gene | 5745 |
| HGNC | 9608 |
| OMIM | 168468 |
| RefSeq | NM_000316 |
| UniProt | Q03431 |
| Other data | |
| Locus | Chr. 3 p22-p21.1 |
| parathyroid hormone 2 receptor | |
|---|---|
| Identifiers | |
| Symbol | PTH2R |
| NCBI gene | 5746 |
| HGNC | 9609 |
| OMIM | 601469 |
| RefSeq | NM_005048 |
| UniProt | P49190 |
| Other data | |
| Locus | Chr. 2 q33 |
References
- Jüppner H (1994). "Molecular cloning and characterization of a parathyroid hormone/parathyroid hormone-related peptide receptor: a member of an ancient family of G protein-coupled receptors". Curr. Opin. Nephrol. Hypertens. 3 (4): 371–8. doi:10.1097/00041552-199407000-00002. PMID 8076140.
- Mannstadt M, Jüppner H, Gardella TJ (1999). "Receptors for PTH and PTHrP: their biological importance and functional properties". Am. J. Physiol. 277 (5 Pt 2): F665–75. PMID 10564229. Archived from the original on 2009-02-13. Retrieved 2007-11-01.
- Offermanns S, Iida-Klein A, Segre GV, Simon MI (1996). "G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells". Mol. Endocrinol. 10 (5): 566–74. doi:10.1210/me.10.5.566. PMID 8732687.
- Usdin TB, Bonner TI, Hoare SR (2002). "The parathyroid hormone 2 (PTH2) receptor". Recept. Channels. 8 (3–4): 211–8. doi:10.1080/10606820213682. PMID 12529938.
External links
- Parathyroid+Hormone+Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
- "Parathyroid Hormone Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
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