MRGPRX2

MRGPRX2
Identifiers
Aliases	MRGPRX2, MGRG3, MRGX2, MAS related GPR family member X2
External IDs	OMIM: 607228 MGI: 3588270 HomoloGene: 24986 GeneCards: MRGPRX2
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	19,060,717 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	48,499,321 bp[2]
Gene ontology
Molecular function	• neuropeptide binding; • signal transducer activity; • mast cell secretagogue receptor activity; • G-protein coupled receptor activity;
Cellular component	• cell membrane; • membrane; • integral component of membrane; • mast cell granule; • integral component of plasma membrane;
Biological process	• sleep; • positive regulation of cytokinesis; • mast cell activation; • G-protein coupled receptor signaling pathway; • signal transduction; • nociception; • mast cell degranulation;
	Sources:Amigo / QuickGO
Orthologs
	117194
	243978
	ENSG00000183695
	ENSMUSG00000074109
	Q96LB1
	Q3UG50
	NM_001303615; NM_054030
	NM_001034868
	NP_001290544; NP_473371
	NP_001030040
	Wikidata
View/Edit Human	View/Edit Mouse

Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene.[5][6] Agonists are gyrase inhibitors like ciprofloxacin and non-steroidal neuromuscular blocking agents like atracurium as well as vancomycin. Activation of MRGPRX2 leads to mast cell degranulation with subsequent pseudo-allergic reactions.

References

GRCh38: Ensembl release 89: ENSG00000183695 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000074109 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (Sep 2001). "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons". Cell. 106 (5): 619–632. doi:10.1016/S0092-8674(01)00483-4. PMID 11551509.
"Entrez Gene: MRGPRX2 MAS-related GPR, member X2".

Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Robas N, Mead E, Fidock M (2004). "MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion". J. Biol. Chem. 278 (45): 44400–44404. doi:10.1074/jbc.M302456200. PMID 12915402.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yang S, Liu Y, Lin AA, et al. (2005). "Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception". Gene. 352: 30–35. doi:10.1016/j.gene.2005.03.001. PMID 15862286.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183695 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074109 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11551509-5] Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (Sep 2001). "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons". Cell. 106 (5): 619–632. doi:10.1016/S0092-8674(01)00483-4. PMID 11551509.

[entrez-6] "Entrez Gene: MRGPRX2 MAS-related GPR, member X2".

MRGPRX2

See also

References

Further reading