LPAR5

Lysophosphatidic acid receptor 5 also known as LPA5 is a protein that in humans is encoded by the LPAR5 gene.[5][6][7][8][9] LPA5 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[10]

LPAR5
Identifiers
AliasesLPAR5, GPR92, GPR93, KPG_010, LPA5, lysophosphatidic acid receptor 5
External IDsOMIM: 606926 MGI: 2685918 HomoloGene: 10696 GeneCards: LPAR5
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12p13.31Start6,618,835 bp[1]
End6,635,960 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

57121

381810

Ensembl

ENSG00000184574

ENSMUSG00000067714

UniProt

Q9H1C0

Q149R9

RefSeq (mRNA)

NM_020400
NM_001142961

NM_001163268
NM_001163269

RefSeq (protein)

NP_001136433
NP_065133

NP_001156740
NP_001156741

Location (UCSC)Chr 12: 6.62 – 6.64 MbChr 6: 125.07 – 125.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

See also

References
  1. GRCh38: Ensembl release 89: ENSG00000184574 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000067714 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23". Nat Genet. 26 (3): 345–8. Dec 2000. doi:10.1038/81664. PMID 11062477.
  6. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
  7. Lee CW, Rivera R, Gardell S, Dubin AE, Chun J (Aug 2006). "GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5". J Biol Chem. 281 (33): 23589–97. doi:10.1074/jbc.M603670200. PMID 16774927.
  8. Kotarsky K, Boketoft A, Bristulf J, Nilsson NE, Norberg A, Hansson S, Owman C, Sillard R, Leeb-Lundberg LM, Olde B (Jul 2006). "Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes". J Pharmacol Exp Ther. 318 (2): 619–28. doi:10.1124/jpet.105.098848. PMID 16651401.
  9. "Entrez Gene: GPR92 G protein-coupled receptor 92".
  10. Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.

Further reading
  • Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.
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