P2RY2

P2Y purinoceptor 2 is a protein that in humans is encoded by the P2RY2 gene.[5][6]

P2RY2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesP2RY2, HP2U, P2RU1, P2U, P2U1, P2UR, P2Y2, P2Y2R, purinergic receptor P2Y2
External IDsOMIM: 600041 MGI: 105107 HomoloGene: 1927 GeneCards: P2RY2
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.4Start73,218,298 bp[1]
End73,236,352 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5029

18442

Ensembl

ENSG00000175591

ENSMUSG00000032860

UniProt

P41231

P35383

RefSeq (mRNA)

NM_002564
NM_176071
NM_176072

NM_008773
NM_001302346
NM_001302347

RefSeq (protein)

NP_002555
NP_788085
NP_788086

NP_001289275
NP_001289276
NP_032799

Location (UCSC)Chr 11: 73.22 – 73.24 MbChr 7: 101 – 101.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The product of this gene, P2Y2 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene.[7]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000175591 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032860 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Parr CE, Sullivan DM, Paradiso AM, Lazarowski ER, Burch LH, Olsen JC, Erb L, Weisman GA, Boucher RC, Turner JT (May 1994). "Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy". Proc Natl Acad Sci USA. 91 (8): 3275–9. doi:10.1073/pnas.91.8.3275. PMC 43559. PMID 8159738.
  6. Somers GR, Hammet F, Woollatt E, Richards RI, Southey MC, Venter DJ (Nov 1997). "Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family". Genomics. 44 (1): 127–30. doi:10.1006/geno.1997.4841. PMID 9286708.
  7. "Entrez Gene: P2RY2 purinergic receptor P2Y, G-protein coupled, 2".

Further reading

  • "P2Y Receptors: P2Y2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

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