GPR110

Probable G-protein coupled receptor 110 is a protein that in humans is encoded by the GPR110 gene.[5][6] This gene encodes a member of the adhesion-GPCR receptor family.[7] Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[8]

ADGRF1
Identifiers
AliasesADGRF1, KPG_012, PGR19, hGPCR36, GPR110, adhesion G protein-coupled receptor F1
External IDsOMIM: 617430 MGI: 1924846 HomoloGene: 124643 GeneCards: ADGRF1
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p12.3|6Start46,997,708 bp[1]
End47,042,350 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

266977

77596

Ensembl

ENSG00000153292

ENSMUSG00000041293

UniProt

Q5T601

Q8VEC3

RefSeq (mRNA)

NM_025048
NM_153840

NM_133776

RefSeq (protein)

NP_079324
NP_722582

NP_598537

Location (UCSC)Chr 6: 47 – 47.04 MbChr 17: 43.27 – 43.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000153292 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000041293 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584.
  6. "Entrez Gene: GPR110 G protein-coupled receptor 110".
  7. Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3.
  8. Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

Further reading

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