Tachykinin receptor
There are three known mammalian tachykinin receptors termed NK1, NK2 and NK3. All are members of the 7 transmembrane G-protein coupled receptor family and induce the activation of phospholipase C, producing inositol triphosphate (so called Gq-coupled).
| Tachykinin receptor | |
|---|---|
| Identifiers | |
| Symbol | ? |
| InterPro | IPR001681 |
| tachykinin receptor 1 | |
|---|---|
| Identifiers | |
| Symbol | TACR1 |
| Alt. symbols | TAC1R |
| NCBI gene | 6869 |
| HGNC | 11526 |
| OMIM | 162323 |
| RefSeq | NM_001058 |
| UniProt | P25103 |
| Other data | |
| Locus | Chr. 2 p13.1-p12 |
| tachykinin receptor 2 | |
|---|---|
| Identifiers | |
| Symbol | TACR2 |
| Alt. symbols | TAC2R, NKNAR |
| NCBI gene | 6865 |
| HGNC | 11527 |
| OMIM | 162321 |
| RefSeq | NM_001057 |
| UniProt | P21452 |
| Other data | |
| Locus | Chr. 10 q11-q21 |
| tachykinin receptor 3 | |
|---|---|
| Identifiers | |
| Symbol | TACR3 |
| NCBI gene | 6870 |
| HGNC | 11528 |
| OMIM | 162332 |
| RefSeq | NM_001059 |
| UniProt | P29371 |
| Other data | |
| Locus | Chr. 4 q25 |
Inhibitors of NK-1, known as NK-1 receptor antagonists, can be used as antiemetic agents, such as the drug aprepitant.[1]
Binding
The genes and receptor ligands are as follows:[2]
| Receptor | Gene | Preferred ligand |
| NK1 | TACR1 | substance P |
| NK2 | TACR2 | neurokinin A |
| NK3 | TACR3 | neurokinin B |
(Hökfelt et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)
See also
- Substance P
- G protein coupled receptors
References
- "Aprepitant". NICE. Retrieved 2020-05-10.
- Maggi CA (September 1995). "The mammalian tachykinin receptors". General Pharmacology. 26 (5): 911–44. doi:10.1016/0306-3623(94)00292-U. PMID 7557266.
External links
- "Tachykinin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- Tachykinin+Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.