Ubrogepant

Ubrogepant, sold under the trade name Ubrelvy, is a medication used for the acute (immediate) treatment of migraine with or without aura (a sensory phenomenon or visual disturbance) in adults.[1] It is not indicated for the preventive treatment of migraine.[1] It is the first drug in the class of oral calcitonin gene-related peptide receptor antagonists approved for the acute treatment of migraine.[1]

Ubrogepant
Clinical data
Trade namesUbrelvy
Other namesMK-1602
AHFS/Drugs.comMonograph
License data
Routes of
administration		By mouth
ATC code
  • none
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
PubChem SID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC29H26F3N5O3
Molar mass549.554 g·mol−1
3D model (JSmol)

The most common side effects are nausea, tiredness and dry mouth.[1] Ubrogepant is contraindicated for co-administration with strong CYP3A4 inhibitors.[1]

It is a small-molecule calcitonin gene-related peptide receptor antagonist.[2][3]

History

The effectiveness of ubrogepant for the acute treatment of migraine was demonstrated in two randomized, double-blind, placebo-controlled trials.[1] In these studies, 1,439 adult patients with a history of migraine, with and without aura, received the approved doses of ubrogepant to treat an ongoing migraine.[1] In both studies, the percentages of patients achieving pain freedom two hours after treatment (defined as a reduction in headache severity from moderate or severe pain to no pain) and whose most bothersome migraine symptom (nausea, light sensitivity or sound sensitivity) stopped two hours after treatment were significantly greater among patients receiving ubrogepant (19–21% depending on the dose) compared to those receiving placebo (12%).[1][4] Patients were allowed to take their usual acute treatment of migraine at least two hours after taking ubrogepant.[1] 23% of patients were taking a preventive medication for migraine.[1]

In December 2019, the U.S. Food and Drug Administration approved Ubrelvy produced by Allergan USA, Inc. for treatment of migraine after onset.[1][5]

References
  1. "FDA approves new treatment for adults with migraine". U.S. Food and Drug Administration (FDA). 23 December 2019. Archived from the original on 23 December 2019. Retrieved 23 December 2019.
  2. Tfelt-Hansen P, Olesen J (April 2011). "Possible site of action of CGRP antagonists in migraine". Cephalalgia. 31 (6): 748–50. doi:10.1177/0333102411398403. PMID 21383046.
  3. Spreitzer H (22 May 2018). "Neue Wirkstoffe: Ubrogepant". Österreichische Apotheker-Zeitung (in German) (11/2018).
  4. Dodick DW, Lipton RB, Ailani J, Lu K, Finnegan M, Trugman JM, Szegedi A (December 2019). "Ubrogepant for the Treatment of Migraine". The New England Journal of Medicine. 381 (23): 2230–2241. doi:10.1056/NEJMoa1813049. PMID 31800988.
  5. Maddipatla M (23 December 2019). "Allergan's acute migraine treatment wins U.S. FDA approval". Reuters. Retrieved 24 December 2019.


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