GPR12

GPR12
Identifiers
Aliases	GPR12, GPCR12, GPCR21, PPP1R84, G protein-coupled receptor 12
External IDs	OMIM: 600752 MGI: 101909 HomoloGene: 3868 GeneCards: GPR12
Gene location (Human)
Chr.	Chromosome 13 (human)[1]
End	26,760,786 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	146,585,239 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• G-protein coupled receptor activity; • signal transducer activity; • phosphatidylcholine binding;
Cellular component	• integral component of membrane; • cell membrane; • integral component of plasma membrane; • membrane;
Biological process	• G-protein coupled receptor signaling pathway; • cellular calcium ion homeostasis; • signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	2835
	14738
	ENSG00000132975
	ENSMUSG00000041468
	P47775
	P35412
	NM_005288
NM_001010941; NM_008151; NM_001359055; NM_001359056; NM_001359057;
	NM_001359058
	NP_005279
NP_001010941; NP_032177; NP_001345984; NP_001345985; NP_001345986;
	NP_001345987
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 12 is a protein that in humans is encoded by the GPR12 gene.[5][6][7]

The gene product of GPR12 is an orphan receptor, meaning that its endogenous ligand is currently unknown. Gene disruption of GPR12 in mice results in dyslipidemia and obesity.[8]

References

GRCh38: Ensembl release 89: ENSG00000132975 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000041468 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, Nagai Y, Yanagihara T (Jan 1994). "Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system". FEBS Lett. 336 (2): 317–322. doi:10.1016/0014-5793(93)80828-I. PMID 8262253.
Song ZH, Modi W, Bonner TI (Feb 1996). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–349. doi:10.1006/geno.1995.1154. PMID 8530049.
"Entrez Gene: GPR12 G protein-coupled receptor 12".
Bjursell, Mikael; Gerdin, Anna-Karin; Jönsson, Marie; Surve, Vikas V.; Svensson, Lennart; Huang, Xu-Feng; Törnell, Jan; Bohlooly-Y, Mohammad (2006-09-22). "G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice". Biochemical and Biophysical Research Communications. 348 (2): 359–366. doi:10.1016/j.bbrc.2006.07.090. ISSN 0006-291X. PMID 16887097.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Uhlenbrock K, Huber J, Ardati A, et al. (2003). "Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells". Cell. Physiol. Biochem. 13 (2): 75–84. doi:10.1159/000070251. PMID 12649592.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–528. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132975 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041468 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8262253-5] Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, Nagai Y, Yanagihara T (Jan 1994). "Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system". FEBS Lett. 336 (2): 317–322. doi:10.1016/0014-5793(93)80828-I. PMID 8262253.

[pmid8530049-6] Song ZH, Modi W, Bonner TI (Feb 1996). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–349. doi:10.1006/geno.1995.1154. PMID 8530049.

[entrez-7] "Entrez Gene: GPR12 G protein-coupled receptor 12".

[8] Bjursell, Mikael; Gerdin, Anna-Karin; Jönsson, Marie; Surve, Vikas V.; Svensson, Lennart; Huang, Xu-Feng; Törnell, Jan; Bohlooly-Y, Mohammad (2006-09-22). "G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice". Biochemical and Biophysical Research Communications. 348 (2): 359–366. doi:10.1016/j.bbrc.2006.07.090. ISSN 0006-291X. PMID 16887097.

GPR12

References

Further reading