Retinoic acid-inducible orphan G protein-coupled receptor
The Retinoic Acid-Inducible orphan G-protein-coupled receptors (RAIG) are a group of four closely related G protein-coupled receptors whose expression is induced by retinoic acid.[1][2][3][4]
| G protein-coupled receptor, family C, group 5, member A | |
|---|---|
| Identifiers | |
| Symbol | GPRC5A |
| Alt. symbols | RAIG1, RAI3 |
| NCBI gene | 9052 |
| HGNC | 9836 |
| OMIM | 604138 |
| RefSeq | NM_003979 |
| UniProt | Q8NFJ5 |
| Other data | |
| Locus | Chr. 12 p13-p12.3 |
| G protein coupled receptor, family C, group 5, member B | |
|---|---|
| Identifiers | |
| Symbol | GPRC5B |
| Alt. symbols | RAIG2 |
| NCBI gene | 51704 |
| HGNC | 13308 |
| OMIM | 605948 |
| RefSeq | NM_016235 |
| UniProt | Q9NZH0 |
| Other data | |
| Locus | Chr. 16 p12 |
| G protein-coupled receptor, family C, group 5, member C | |
|---|---|
| Identifiers | |
| Symbol | GPRC5C |
| Alt. symbols | RAIG3 |
| NCBI gene | 55890 |
| HGNC | 13309 |
| OMIM | 605949 |
| RefSeq | NM_022036 |
| UniProt | Q9NQ84 |
| Other data | |
| Locus | Chr. 17 q25 |
| G protein-coupled receptor, family C, group 5, member D | |
|---|---|
| Identifiers | |
| Symbol | GPRC5D |
| NCBI gene | 55507 |
| HGNC | 13310 |
| OMIM | 607437 |
| RefSeq | NM_018654 |
| UniProt | Q9NZD1 |
| Other data | |
| Locus | Chr. 12 p13.3 |
The exact function of these proteins has not been determined but they may provide a mechanism by which retinoic acid can influence G protein signal transduction cascades. In addition, RAIG receptors interact with members of the frizzled class of G protein-coupled receptors and appear to activate the Wnt signaling pathway.[5]
References
- Cheng Y, Lotan R (1998). "Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor". J. Biol. Chem. 273 (52): 35008–15. doi:10.1074/jbc.273.52.35008. PMID 9857033.
- Bräuner-Osborne H, Krogsgaard-Larsen P (2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain". Genomics. 65 (2): 121–8. doi:10.1006/geno.2000.6164. PMID 10783259.
- Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (2000). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)". Genomics. 67 (1): 8–18. doi:10.1006/geno.2000.6226. PMID 10945465.
- Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P (2001). "Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D". Biochim. Biophys. Acta. 1518 (3): 237–48. doi:10.1016/s0167-4781(01)00197-x. PMID 11311935.
- Harada Y, Yokota C, Habas R, Slusarski DC, He X (2007). "Retinoic Acid-Inducible G Protein-Coupled Receptors Bind to Frizzled Receptors and May Activate Non-canonical Wnt Signaling". Biochem. Biophys. Res. Commun. 358 (4): 968–75. doi:10.1016/j.bbrc.2007.04.208. PMC 2854581. PMID 17521608.
External links
- "GPRC5 (RAIG) Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- GPRC5A+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- GPRC5B+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- GPRC5C+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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