CatSper2

CATSPER2
Identifiers
AliasesCATSPER2, CatSper2, cation channel sperm associated 2
External IDsMGI: 2387404 HomoloGene: 77423 GeneCards: CATSPER2
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q15.3Start43,628,503 bp[1]
End43,668,118 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

117155

212670

Ensembl

ENSG00000166762

ENSMUSG00000033486

UniProt

Q96P56

A2ARP9

RefSeq (mRNA)

NM_001282309
NM_001282310
NM_054020
NM_172095
NM_172097

NM_153075

RefSeq (protein)

NP_001269238
NP_001269239
NP_742093

n/a

Location (UCSC)Chr 15: 43.63 – 43.67 MbChr 2: 121.39 – 121.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CatSper2, is a protein which in humans is encoded by the CATSPER2 gene.[5][6] CatSper2 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells.[7]

Function

Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000166762 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033486 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Quill TA, Ren D, Clapham DE, Garbers DL (October 2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. doi:10.1073/pnas.221454998. PMC 60087. PMID 11675491.
  6. ↑ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101.
  7. ↑
    • "CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
  8. ↑ "Entrez Gene: CatSper2".

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Zhang D, Chen J, Saraf A, et al. (2006). "Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity". J. Biol. Chem. 281 (31): 22332–41. doi:10.1074/jbc.M511288200. PMID 16740636.
  • Garbers DL (2001). "Ion channels. Swimming with sperm". Nature. 413 (6856): 579, 581–2. doi:10.1038/35098164. PMID 11595929.
  • Quill TA, Ren D, Clapham DE, Garbers DL (2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. doi:10.1073/pnas.221454998. PMC 60087. PMID 11675491.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Clapham DE, Garbers DL (2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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