40S ribosomal protein S7

RPS7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UG0, 4V6X, 5A2Q, 5AJ0, 3J7P, 4KZX, 4UJE, 4KZY, 4D5L, 4KZZ, 3J7R, 4UJD, 5FLX, 4D61, 4UJC
Identifiers
Aliases	RPS7, DBA8, S7, ribosomal protein S7, eS7
External IDs	MGI: 1333818 HomoloGene: 107159 GeneCards: RPS7
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	3,580,919 bp[1]
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)[2]
End	28,635,953 bp[2]
Gene ontology
Molecular function	• structural constituent of ribosome; • protein binding; • RNA binding; • mRNA 3'-UTR binding; • mRNA 5'-UTR binding; • ubiquitin ligase inhibitor activity; • protein kinase binding; • poly(U) RNA binding;
Cellular component	• cytosol; • ribosome; • membrane; • focal adhesion; • intracellular ribonucleoprotein complex; • intracellular; • microtubule organizing center; • nucleolus; • extracellular exosome; • cytoskeleton; • cell nucleus; • nucleoplasm; • extracellular matrix; • cytoplasm; • 90S preribosome; • small-subunit processome; • centrosome; • protein complex; • cytosolic small ribosomal subunit;
Biological process	• viral transcription; • SRP-dependent cotranslational protein targeting to membrane; • translational initiation; • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; • ribosomal small subunit biogenesis; • rRNA processing; • translation; • cytoplasmic translation; • positive regulation of gene expression; • protein stabilization; • positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; • negative regulation of ubiquitin protein ligase activity; • negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	6201
	20115
	ENSG00000171863
	ENSMUSG00000061477
	P62081
	P62082
	NM_001011
	NM_011300
	NP_001002
	NP_035430
	Wikidata
View/Edit Human	View/Edit Mouse

40S ribosomal protein S7 is a protein that in humans is encoded by the RPS7 gene.^[5]^[6]^[7]

In eukaryotes, ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000171863 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000061477 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Annilo T, Laan M, Stahl J, Metspalu A (Jan 1996). "The human ribosomal protein S7-encoding gene: isolation, structure and localization in 2p25". Gene. 165 (2): 297–302. doi:10.1016/0378-1119(95)00576-R. PMID 8522193.
↑ Gorbea C, Taillandier D, Rechsteiner M (Feb 2000). "Mapping subunit contacts in the regulatory complex of the 26 S proteasome. S2 and S5b form a tetramer with ATPase subunits S4 and S7". J Biol Chem. 275 (2): 875–82. doi:10.1074/jbc.275.2.875. PMID 10625621.
1 2 "Entrez Gene: RPS7 ribosomal protein S7".

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
Mundus DA, Bulygin KN, Yamkovoy VI, et al. (1993). "Structural arrangement of the codon-anticodon interaction area in human placenta ribosomes. Affinity labelling of the 40S subunits by derivatives of oligoribonucleotides containing the AUG codon". Biochim. Biophys. Acta. 1173 (3): 273–82. doi:10.1016/0167-4781(93)90124-v. PMID 8318536.
Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
Jäkel S, Görlich D (1998). "Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells". EMBO J. 17 (15): 4491–502. doi:10.1093/emboj/17.15.4491. PMC 1170780. PMID 9687515.
Jäkel S, Mingot JM, Schwarzmaier P, et al. (2002). "Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains". EMBO J. 21 (3): 377–86. doi:10.1093/emboj/21.3.377. PMC 125346. PMID 11823430.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: Native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.
Tompkins V, Hagen J, Zediak VP, Quelle DE (2006). "Identification of novel ARF binding proteins by two-hybrid screening". Cell Cycle. 5 (6): 641–6. doi:10.4161/cc.5.6.2560. PMID 16582619.
Chen D, Zhang Z, Li M, et al. (2007). "Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function". Oncogene. 26 (35): 5029–37. doi:10.1038/sj.onc.1210327. PMID 17310983.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000171863 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000061477 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid8522193-5] Annilo T, Laan M, Stahl J, Metspalu A (Jan 1996). "The human ribosomal protein S7-encoding gene: isolation, structure and localization in 2p25". Gene. 165 (2): 297–302. doi:10.1016/0378-1119(95)00576-R. PMID 8522193.

[pmid10625621-6] Gorbea C, Taillandier D, Rechsteiner M (Feb 2000). "Mapping subunit contacts in the regulatory complex of the 26 S proteasome. S2 and S5b form a tetramer with ATPase subunits S4 and S7". J Biol Chem. 275 (2): 875–82. doi:10.1074/jbc.275.2.875. PMID 10625621.

[entrez-7] 1 2 "Entrez Gene: RPS7 ribosomal protein S7".

40S ribosomal protein S7

References

Further reading